摘要
【目的】探讨降浊化痰理肺方对高血压合并睡眠呼吸暂停(OSA)患者(痰浊内阻证)认知功能的影响。【方法】将138例高血压合并OSA伴认知功能下降患者随机分为治疗组和对照组,每组各69例。治疗组给予西医常规治疗+口服降浊化痰理肺中药颗粒治疗,对照组给予西医常规治疗+口服降浊化痰理肺中药安慰剂治疗,疗程24周。观察2组患者治疗前后蒙特利尔量表(MoCA)评分及血脂、同型半胱氨酸(Hcy)等指标的变化情况,评估2组的降压疗效和中医证候疗效。【结果】(1)治疗24周后,治疗组的降压疗效和中医证候疗效均优于对照组(P<0.05)。(2)治疗后,2组收缩压及舒张压均较治疗前下降(P<0.05),且治疗组对收缩压及舒张压的下降作用均优于对照组(P<0.05)。(3)治疗后,2组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平及治疗组Hcy水平较治疗前下降(P<0.05),且治疗组在降低Hcy水平方面优于对照组(P<0.05)。(4)治疗后,治疗组患者认知功能MoCA量表各项评分及其总分均较治疗前提高(P<0.05或P<0.01),对照组仅视空间与执行、命名能力评分及其总分较治疗前提高(P<0.05或P<0.01),治疗组在提高视空间与执行、记忆、语言能力及总分方面优于对照组(P<0.05)。【结论】降浊化痰理肺颗粒治疗高血压合并OSA患者,具有较好疗效,能有效降低患者的血压和Hcy水平,改善患者的认知功能,提高患者的生活质量。
Objective To observe the effect of Turbid-descending,Phlegm-resolving and Lung-regulating Recipe（TPLR）on cognitive function in patients with hypertension complicated with obstructive sleep apnea（OSA）.Methods One hundred and thirty-eight cases of patients with hypertension complicated with OSA and declinedcognitive ability were randomly divided into treatment group and control group, 69 cases in each group. Thetreatment group was given routine western medicine treatment and oral use of TPLR,and the control group wasgiven routine western medicine treatment and oral use of the placebo of TPLR,the treatment lasting for 24 weeks.The scores of Montreal Cognitive Assessment（MoCA）and the indexes including blood lipids and homocysteine（Hcy）were observed in the two groups before and after treatment. The clinical effects on lowering blood pressureand improving traditional Chinese medicine（TCM）syndromes were evaluated in the two groups. Results（1）Aftertreatment for 24 weeks, the clinical effects on lowering blood pressure and improving TCM syndromes in thetreatment group were superior to those in the control group（P〈0.05）.（2）After treatment,the systolic pressure anddiastolic pressure were decreased in the two groups as compared with those before treatment（P〈0.05）,and thedecrease in the treatment group was superior to that in the control group（P〈0.05）.（3）After treatment,the levelsof total cholesterol（TC）,triglyceride（TG）and low density lipoprotein cholesterin（LDL-C）in the two groups aswell as the level of Hcy in the treatment group were decreased as compared with those before treatment（P〈0.05）,and the decrease of Hcy in the treatment group was superior to that in the control group（P〈0.05）.（4）The scores ofvarious items of MoCA and the total scores in the treatment group were higher than those before treatment（P〈0.05 or P〈0.01）,and the scores of visual space,execution and name ability,and the total scores in the control groupwere higher than those before treatment（P〈0.05 or P〈0.01）. The increase of visual space,execution,memoryand language ability as well as the total scores in the treatment group was superior to that in the control group（P〈0.05）. Conclusion TPLR has certain effect for the treatment of patients with hypertension complicated with OSA by decreasing blood pressure and Hcy level,improving cognitive functions,and enhancing the quality of life.
作者
张积友
常晓艳
江芳超
徐文刚
ZHANG Ji-You;CHANG Xiao-Yan;JIANG Fang-Chao;XU Wen-Gang(Dept.of Respiratory Medicine,Qingdao Integrated Traditional Chinese and Western Medicine Hospital,Qingdao 266002 Shandong,China;Dept.of General Practice,Qingdao Hiser Hospital,Qingdao 266000 Shandong,China)
出处
《广州中医药大学学报》
CAS
2018年第6期986-992,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
青岛市卫生科技计划项目(编号:2014-WJZD054)
关键词
降浊化痰理肺方
高血压
睡眠呼吸暂停
认知功能
生活质量
Turbid-descending,Phlegm-resolving and Lung-regulating Recipe
hypertension
obstructive sleep apnea
cognitive function
quality of life
