摘要
目的:探讨血塞通胶囊联合阿托伐他汀用于脑梗死恢复期的效果及安全性。方法:回顾性选取2016年北京市海淀区羊坊店医院收治的脑梗死恢复期患者98例,按治疗方法的不同分为观察组50例和对照组48例。对照组患者给予阿托伐他汀,观察组患者在对照组的基础上加用血塞通胶囊。观察两组患者的临床疗效、血脂水平、血液流变学指标、生活质量评分及不良反应发生情况。结果:观察组患者的总有效率为92.00%(46/50),明显高于对照组的72.92%(35/48),差异有统计学意义(P<0.05);治疗后,观察组患者总胆固醇、三酰甘油、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇水平明显优于治疗前及对照组治疗后,差异均有统计学意义(P<0.05);治疗后,观察组患者红细胞比容、全血高切黏度、全血低切黏度及血浆高切黏度水平明显优于治疗前及对照组治疗后,差异均有统计学意义(P<0.05);治疗后,两组患者美国国立卫生研究院卒中量表、日常生活能力量表评分较治疗前明显改善,且观察组患者明显优于对照组,差异均有统计学意义(P<0.05);治疗期间,两组患者均未见明显不良反应。结论:血塞通胶囊联合阿托伐他汀用于脑梗死恢复期的效果较好,可明显改善患者的血脂、血液流变学指标,提高患者的生活质量,且未见明显不良反应。
OBJECTIVE：To probe into the efficacy and safety of Xuesaitong capsule combined with atorvastatin in treatment of cerebral infarction in recovery period. METHODS： 98 patients with cerebral infarction in recovery period admitted into Beijing Haidian District Yangfangdian Hospital in 2016 were retrospectively selected and divided into observation group（50 cases） and control group（48 cases） according to different therapies. The control group was treated with atorsvastatin, while the observation group was given Xuesaitong capsule combined with atorvastatin. The clinical efficacy, blood lipid levels, hemorheological indices, life quality scores and incidences of adverse drug reactions of two groups were observed. RESULTS： The total effective rate of observation group was 92.00%（46/50）, which was significantly higher than that of the control group（72.92%, 35/48）, with statistically significant difference（P0.05）; after treatment, the TC, TG, LDL-C and HDL-C levels of observation groups were significantly better than those of before treatment and the control group, with statistically significant differences（P0.05）; after treatment, the hematocrit value, whole blood high shear viscosity, whole blood low shear viscosity and plasma high shear viscosity of observation group were significantly better than those of before treatment and the control group, with statistically significant differences（P0.05）; after treatment, the NIHSS and ADL scores of both groups had been significantly improved, and those of the observation group were significantly better than the control group, with statistically significant differences（P0.05）; during treatment, no significant adverse drug reactions were observed in either group. CONCLUSIONS： The efficacy of Xuesaitong capsule combined with atorvastatin in treatment of cerebral infarction in recovery period is remarkable, which can significantly improve blood lipid level, hemorheological indices and life quality, with no significant adverse drug reactions.
作者
李玉安
李琦
LI Yu＇an;LI Qi(Dept.of General,Beijing Haidian District Dongsheng Community Healthcare Center,Beijing 100053,China;Dept.of Medicine,Beijing Haidian District Yangfangdian Hospital,Beijing 100038,China)
出处
《中国医院用药评价与分析》
2018年第10期1357-1359,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
血塞通胶囊
阿托伐他汀
脑梗死恢复期
不良反应
Xuesaitong capsule
Atorvastatin
Recovery period of cerebral infarction
Adverse reaction
