摘要
目的探讨联合检测尿液α_1-微球蛋白(α_1-MG)、血清_(β2)-微球蛋白(β_2-MG)、胱抑素C(Cys-C)在慢性肾小球肾炎(CG)早期诊断中的应用价值。方法选取该院2012年3月至2017年3月内分泌科、肾内科的门诊及住院部收治的CG伴早期肾功能损害的患者58例(疾病组),以及同期到该院体检的60例健康体检者(对照组)作为研究对象,回顾性分析两组检测尿液α_1-MG和血清_(β2)-MG、Cys-C、肌酐(SCr)、尿素(SUrea)的结果。结果疾病组尿液α_1-MG和血清_(β2)-MG、Cys-C水平高于对照组,差异有统计学意义(P<0.05),SCr和SUrea水平高于对照组,差异无统计学意义(P>0.05)。在疾病组中尿液α_1-MG和血清_(β2)-MG、Cys-C单项指标阳性检出率分别为62.07%,67.24%和65.52%,低于3项指标联合检测阳性检出率(91.38%),差异有统计学意义(P<0.05)。结论尿液α_1-MG和血清_(β2)-MG、Cys-C是诊断CG早期肾功能的理想的指标,3项指标联合检测有利于提高CG早期肾功能损害的检出率。
Objective Discuss application value of joint detection of urinary alpha 1-microglobulin （α 1-MG） serum beta2- microglobulin （β 2-MG）,cystatin C （Cys-C） in the early diagnosis of chronic glomerulonephritis （CG）. Methods Random selection of our hospital endocrine,nephrology outpatient and hospitalization in March 2012 to 2017 March between CG were treated with early renal damage in hospital patients in 58 cases （disease group） and 60 cases of healthy persons （control group） as the research object,the results of two groups were retrospectively analyzed for urinary α 1-MG and serum β 2-MG,Cys-C,Creatinine （SCr）,and urea （SUrea）. Results In disease group urinary α 1-MG and serum β 2-MG,Cys-C were higher than those in control group,and the difference was statistically significant （ P 〈0.01）,SCr and SUrea higher than the control group,the difference was not statistically significant （ P 〉0.05）.in the disease group urinary α 1-MG and serum β 2-MG,Cys-C,the positive detection rate of individual indicators were 62.07%,67.24% and 65.52 %,the positive rate was 91.38% lower than that of three indexes.,and the difference was statistically significant （ P 〈 0.05）. Conclusion Urinary α 1-MG and serum β 2-MG,Cys-C is an ideal laboratory indicator for the diagnosis of early renal function in CG,in the early stage of CG,the changes of renal function should be closely monitored during the course of treatment.three indicators combined detection is beneficial to improve the detection rate of early renal function damage in CG,which can provide reliable laboratory evidence for the early detection,diagnosis and treatment of CG in the basic hospital.
作者
刘琳
李林英
潘柏莉
向省平
LIU Lin;LI Linying;PAN Boli;XIANG Shengping(Hospital of Chengdu Resident Office of PeoPle＇s Government of the Tibetan Autonomous Region,Chengdu,Sichuan 610041,China)
出处
《检验医学与临床》
CAS
2018年第22期3408-3410,共3页
Laboratory Medicine and Clinic
