摘要
目的探讨MR扩散张量成像（DTI）定量参数评估非动脉炎性前部缺血性视神经病变（NAION）进展程度的价值。方法收集2015年6月至2017年8月，确诊为NAION的38例患者的56只眼作为NAION组，根据发病时间分为急性期17只眼、进展期16只眼、慢性期23只眼；按照年龄、性别匹配原则，纳入38名健康志愿者的56只眼作为对照组。所有受试者均行MR及DTI检查，对原始图像后处理后获得平均扩散率（MD）、平行扩散率（λ//）、垂直扩散率（λ┴）、部分各向异性（FA）、纤维束长度（Length）值。采用独立样本t检验比较NAION组与对照组间各参数值的差异；采用单因素方差分析比较NAION组不同时期患者间各参数值的差异。
结果NAION组的FA、Length值分别为0.20±0.11、（5.85±0.92）mm，较对照组[0.31±0.12、（65.11±6.89）mm]降低，差异均有统计学意义（t=－4.28、－5.25，P〈0.05）；NAION组MD、λ┴值分别为（0.16±0.04）×10-3、（0.16±0.05）×10-3 mm2/s，较对照组[（0.10±0.04）×10-3、（0.09±0.03）×10-3 mm2/s]升高，差异均有统计学意义（t=6.83、7.10，P〈0.05）。NAION组急性期、进展期和慢性期患者分别与相应的对照组相比，各期的FA、Length值降低，MD、λ┴值升高，差异均有统计学意义（P〈0.05）。NAION组急性期、进展期及慢性期患者间FA值的差异有统计学意义（F=10.88，P〈0.05），MD、λ//、λ┴及Length值的差异无统计学意义（F值分别为0.23、0.64、0.33、1.38；P值分别为0.79、0.54、0.72和0.27）。NAION组急性期与慢性期、进展期与慢性期之间FA值的差异均有统计学意义（P〈0.05）。结论DTI定量参数可用于评估NAION患者不同进展阶段的视神经损害程度。
ObjectiveTo study the feasibility and value of magnetic resonance diffusion tensor imaging （DTI） to monitor non-arteritic anterior ischemic optic neuropathy （NAION）.MethodsThirty eight NAION patients （56 eyes） were divided into acute period in 17 eyes, progressive period in 16 eyes and chronic period in 23 eyes at the base of onset time. According to matching principle, 56 eyes in 38 normal controls （NCs） were enrolled. All the patients and NCs underwent MR and DTI scan. The raw data were processed by two experienced radiologists, mean diffusivity （MD）, axial diffusivities （λ//）, radial diffusivities （λ┴）, fractional anisotropy （FA） and Length value were got. The independent sample t test was used for the parameter values between the NAION group and the NCs group. A single factor variance analysis was used to compare the parameters among different stages of NAION group.ResultsCompared to the NCs group, the values of FA and Length in NAION group were reduced [0.20±0.11 vs 0.31±0.12, （5.85±0.92） vs （65.11±6.89） mm], and the differences were statistically significant （t=-4.28, -5.25; P〈0.05）. The values of MD and λ┴ were increased [（0.16±0.04）×10-3 vs （0.10±0.04）×10-3 mm2/s, （0.16±0.05）×10-3 vs （0.09±0.03）×10-3 mm2/s] in NAION group and the differences were statistically significant （t=6.83, 7.10; P〈0.05）. The value of FA and Length in acute period, progressive period and chronic period of the NAION group decreased differently compared to the NCs group. At the same time, the value of MD value and λ┴ in the three periods of the NAION group increased compared to the NCs groupand the differences were statistically significant （P〈0.05）. The value of FA between the acute period, the progressive period, and the chronic period of NAION group were statistically signficant （F=10.88, P〈0.05）. However, no significant differences were found in the values of MD, λ┴ and Length of the NAION group （F=0.23, 0.64, 0.33, 1.38; P=0.79, 0.54, 0.72, 0.27）.ConclusionThe parameters of DTI can be used to monitor the damage of optic nerve and development in NAION.
作者
郭鹏德
赵朋波
赵晶
苏艳
刘明
陈云翔
王伟新
王岩
华海琴
康少红
蔡玲玲
张婷
Guo Pengde;Zhao Pengbo;Zhao Jing;Su Yan;Liu Ming;Chen Yunxiang;Wang Weixin;Wang Yan;Hua Haiqin;Kang Shaohong;Cai Lingling;Zhang Ting(Department of Radiology,Dongfang Hospital,Belting University of Chinese Medicine,Belting 100078,China)
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2018年第10期761-765,共5页
Chinese Journal of Radiology
基金
北京中医药大学基本科研业务费项目（2015-JYB-JSMS107）
关键词
视神经疾病
磁共振成像
扩散张量成像
Optic nerve diseases
Magnetic resonance imaging
Diffusion tensor imaging
