摘要
目的探讨血管内皮生长因子(VEGF) 634G/C和2578C/A位点基因多态性与不同临床分型慢性HBV感染的相关性。方法纳入200例慢性HBV感染患者,其中慢性乙型肝炎、重型乙型肝炎、乙型肝炎相关性肝硬化和乙型肝炎相关性肝癌各50例,另取60例健康体检者作为对照组。比较不同临床分型慢性HBV感染患者的VEGF 634G/C位点和2578C/A位点基因型及等位基因的分布情况,分析VEGF 634G/C、2578C/A位点基因型与不同临床分型慢性HBV感染的关联性。结果各临床分型患者的634G/C位点基因型及其等位基因频率分布差异均有统计学意义(均P <0. 05),但2578C/A位点基因型频率及其等位基因频率分布差异均无统计学意义(均P> 0. 05)。相比于GC基因型,634G/C位点CC基因型是发生重型乙型肝炎的保护因素(P <0. 05);相比于CA基因型,2578C/A位点CC基因型是肝硬化和肝癌发生的危险因素(P <0. 05)。结论携带VEGF 634G/C位点CC基因型者患重型乙型肝炎的风险降低,携带VEGF 2578C/A位点CC基因型者患肝硬化及肝癌的风险增加。
Objective To investigate the correlation of vascular endothelial growth factor（ VEGF ） 634G/C and 2578C/A loci gene polymorphisms with chronic HBV infection of various clinical subtypes. Methods A total of 200 patients with chronic HBV infection were enrolled,including 50 cases of chronic hepatitis B,50 cases of severe hepatitis B,50 cases of hepatitis B-related cirrhosis and 50 cases of hepatitis B-related liver cancer.Another 60 check-up healthy patients were enrolled as the control group.The genotype and allele distribution of VEGF - 634G/C and -2578C/A loci were compared among chronic HBV infection of various clinical subtypes,and the correlation was analyzed between VEGF -634G/C and -2578C/A loci genotypes and chronic HBV infection of various clinical subtypes. Results Among the patients with various clinical subtypes,there were statistically significant differences in the genotype and allele frequency distribution of 634G/C locus（all P 〈0.05）,however,no statistically significant difference was found in the genotype or allele frequency distribution of 2578C/A locus（all P 〉0.05）.Compared with GC genotype,634G/C locus of CC genotype was a protection factor for severe hepatitis B（ P 〈0.05）;compared with CA genotype,2578C/A locus of CC genotype was a risk factor for cirrhosis and liver cancer （ P 〈0.05）. Conclusion The VEGF -634G/C locus carriers of CC genotype have a decreased risk of severe hepatitis B,and the VEGF -2578C/A locus carriers of CC genotype have an increased risk of cirrhosis and liver cancer.
作者
柏立婧
杨宝山
BAI Li-jing;YANG Bao-shan(Department of Clinical Laboratory,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Infectious Diseases,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《广西医学》
CAS
2018年第20期2388-2391,2407,共5页
Guangxi Medical Journal
基金
黑龙江省教育厅科学技术研究项目(1155lz010)
