摘要
目的 探讨家兔心肌梗死急性期曲马多对心肌的保护作用。方法 2 5～ 3kg家兔 16只 ,随机分为 2组 ,对照组 (control) :单纯结扎冠状动脉左对角支 ;曲马多组 (tramadol) :于结扎前 10min静脉注射曲马多 10mg ,并于结扎后 3h等量补充。各组均行左股动脉穿刺监测平均动脉压 (MAP) ,并分别于给药及结扎前 (basic)、结扎后 3h、结扎后 6h抽取颈外静脉血 ,测血中一氧化氮 (NO)含量。结果 MAP :对照组在结扎后明显降低 (P <0 0 1) ,曲马多组结扎前后变化不明显。NO值 :对照组在结扎后较基础明显降低 (P <0 0 5 ) ,曲马多组在结扎后与基础值相比差异无显著性 ,曲马多组在结扎后 3h与基础的差值明显高于对照组同时点的差值 (P <0 0 1) ,在结扎后 6h与基础的差值 2组差异不显著。结论 心肌梗死急性期曲马多可以升高循环血中NO水平 。
Objective To investigate the myocardial protective effects of tramadol during acute myocardial infarction. Methods Sixteen rabbits (2.5～3 kg) were randomly divided into two groups, control group:only left coronary artery was occluded; tramadol group: tramadol 10 mg was administered intravenously 10 min before occluding and administered again 3 h after occluding. MAP was monitored in all animals. The serum levels of nitric oxide were measured before and 3,6 h after occluding. Result MAP of control group was reduced after occluding (P<0.01), the changes of tramadol groups were not observed; the nitric oxide value reduced in control group after occluding (P<0.05) while that of tramadol group remained unchanged. Conclusion Tramadol increased NO level in blood circulation and plays an important myocardial preservation role during acute myocardial infarction.
出处
《中国急救医学》
CAS
CSCD
北大核心
2002年第9期514-515,共2页
Chinese Journal of Critical Care Medicine
