摘要
目的探析氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的临床效果。方法回顾性分析在2014年2月—2017年8月期间该院收治的55例老年短暂性脑缺血患者的临床资料,按治疗方法分为对照组和治疗组,其中对照组30例,治疗组25例。对照组采取阿司匹林抗血小板聚集,他汀类调脂稳定斑块,营养神经,活血化瘀,清除自由基等治疗;治疗组在对照组基础上,联合氯吡格雷。比较两组凝血指标各项参数,分析治疗效果。结果治疗组总有效率92.00%显著高于对照组76.67%,比较差异有统计学意义(χ~2=4.847,P<0.05);经治疗,治疗组APTT(34±3.4)s、PT (16.2±1.5)s、TT (17±2.1)s及FIB (5.04±0.5)g/L均高于治疗组,两者相比差异有统计学意义(t=4.272、4.384、4.001、4.182,P<0.05)。结论氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作能够显著提高治疗效果,能有效改善患者的相关血流指标,降低炎性因子对机体的不良反应。该方法值得在临床上应用并推广。
Objective To analyze the clinical effect of clopidogrel combined with aspirin in the treatment of transient ischemic attack in the elderly. Methods The clinical data of 55 elderly patients with transient cerebral ischemia admitted to the hospital from February 2014 to August 2017 were retrospectively analyzed. The treatment was divided into control group and treatment group, including 30 cases in the control group, and treatment group of 25 cases. The control group took aspirin anti-platelet aggregation, statin lipid-lowering stabilized plaque, nourishing nerve, promoting blood circulation and removing blood stasis, and scavenging free radicals. The treatment group was combined with clopidogrel on the basis of the control group. The parameters of the two groups were compared and the therapeutic effects were analyzed. Results The total effective rate of the treatment group was 92.00%, which was significantly higher than that of the control group （76.67%）. The difference was statistically significant （X^2=4.847, P〈0.05）. After treatment, the treatment group had APTT （34±3.4）s and PT（16.2±1.5）s. TT （17±2.1）s and FIB （5.04±0.5）g/L were higher than the treatment group, and the difference were statisti- cally significant （t=4.272, 4.384, 4.001, 4.182, P〈0.05）. Conclusion Clopidogrel combined with aspirin in the treatment of transient ischemic attack in the elderly can significantly improve the therapeutic effect, can effectively improve the relevant blood flow indicators of patients, and reduce the adverse reactions of inflammatory factors on the body. This method is worthy of clinical application and promotion.
作者
傅国强
FU Guo-qiang(Department of Emergency,Xiyuan District,Second People＇s Hospital of Lianyungang City,Lianyungang,Jiangsu Province,222023 China)
出处
《中外医疗》
2018年第27期126-128,共3页
China & Foreign Medical Treatment
