摘要
目的 探讨胃息肉的组织学分型与幽门螺杆菌 (HP)感染的关系。 方法 111例胃息肉按王梅先的组织学分类法进行分类 ,硼酸美兰染色进行HP检测 ,对其中 37例肿瘤性息肉进行增殖细胞核抗原 (PCNA)、癌基因p5 3免疫组化染色。 结果 111例中发现 6 3例息肉有HP感染 ,阳性率为 5 4.95 % ,乳头状腺瘤的HP感染显著高于其他类型息肉 (χ2 =2 5 .47,P <0 .0 5 ) ;乳头状腺瘤伴异型上皮灶最多 (占 38.46 % )。免疫组化结果HP感染组的PCNA阳性表达高于未感染组 ,2例重度异型增生的乳头状腺瘤p5 3表达阳性 ,且伴有HP感染及PCNA强阳性表达 ,随访后发现癌变。 结论 HP感染可能与肿瘤性息肉的癌变及非肿瘤性息肉的发生有关。
Objective To study the histological types of gastric polyp and their relations with HP infection. Methods 111 cases of gastric polyp were classificated with the histological standard of Wang Meixian and HP were detected by boric acid methylene blue staining.Among them,37 cases of tumor polyp were studied immuno-histochemically with proliferating cell nuclear antigen (PCNA) and p53 protein. Results 63 cases were infected HP,the HP positive rates was 54.95%.The difference of HP positive rates between papillary adenoma and other groups was significant (χ 2=25.47,P<0.05).Heterotypic epithelium was more frequently detected in papillary adenomas,the positive rate was 38.64%.Immunohistochemistry showed that there was more PCNA expression in HP positive group than in HP negative group.After follow-up,canceration was found in two cases of papillary adnoma with severe dysplasia and expression of p53,PCNA. Conclusion HP infection may be related to the canceration of tumor polyp and formation of non-tumor polyp.
出处
《宁波医学》
2000年第10期462-463,共2页
