摘要
采用反相高效液相色谱法测定不同比例配伍的当归补血汤中阿魏酸的煎出率，并进一步观察了它们对小鼠吞噬功能和免疫器官的影响。结果表明：当归补血汤按经典的当归一黄芪（１：５）配伍时，阿魏酸的煎出率最高；并且当归一黄芪按１：５和５：１配伍时其阿魏酸的煎出率均明显高于按１：１配伍者。药理实验亦表明：当归一黄芪（１：５）配伍的当归补血汤提高小鼠廓清指数（Ｋ）和吞噬指数（α）的作用明显强于其它比例配伍者。
Using reversal HPLC, yields of ferulic acid isolated from Danggui Buxue decoction(DBD)with various proporations of its two ingredients,Radix Angelicae Sinensis(RAS)and Radix Astragali(RAH),were comparatively esti-mated.Furthermore,effects of extracts from DBD with different ingredient pro-porations on phagocytic function and immune organs were also explored in mice.The highest yield of ferulic acid was obtained when a classical ratio of RAS and RAH(1:5) in DBD was adopted.The yield of ferulic acid from DBD with a 1:5 or a 5:1 ratio between RAS and RAH was much higher than that with a 1:1 ratio of t he two ingredients. Pharmacological data showed that efficacy of in-creasing clearance index(K)and phagocytic index(α)by DBD with the 1:5ratio of RAS and RAH was more potent than that by DBD with other ratios ofthe two ingredients.
出处
《中国实验方剂学杂志》
CAS
1995年第1期33-37,共5页
Chinese Journal of Experimental Traditional Medical Formulae
