摘要
目的：通过研究不同粉体性质的磷酸氢钙对挥发性成分丹皮酚的吸附及解吸特性,对磷酸氢钙作为吸收剂应用的性能进行评价。方法：以丹皮酚为模型药物,2种不同粉体性质的磷酸氢钙（SG-Ⅰ和SG-Ⅱ）为吸收剂,通过丹皮酚吸附动力学模型和等温曲线模型的拟合,以丹皮酚吸附量及吸附速率为指标,结合比表面积、孔体积、孔径等粉体参数,比较2种磷酸氢钙的吸附能力;并对所得的吸附分散物进行溶出度考察。结果：2种磷酸氢钙吸附丹皮酚的过程均符合伪二级动力学模型,SG-Ⅱ的吸附速率参数（15.832 g·g（-1）·h（-1））高于SG-Ⅰ的（8.183 g·g（-1）·h（-1））;在所选质量浓度范围内,2种磷酸氢钙吸附过程均更好地符合Freundlich吸附等温模型,SG-Ⅱ的丹皮酚平衡吸附量（0.926 g·g-1）高于SG-Ⅰ的（0.508 g·g（-1））。在2种溶出介质中,SG-Ⅰ和SG-Ⅱ的丹皮酚吸附分散物的解吸附过程均符合伪二级动力学模型;在相同溶出介质中,2种吸附分散物中丹皮酚的解吸附速率相近。结论：比表面积、孔体积、孔径大的SG-Ⅱ吸附能力优于SG-Ⅰ,两者解吸附能力相近。
Objective： To evaluate the properties of calcium hydrogen phosphate as an absorbent,effect of calcium hydrogen phosphate with different powder properties on the adsorption and desorption characteristics of paeonol was investigated. Method： Taking paeonol as a model drug and two kinds of calcium hydrogen phosphate（ SG-Ⅰ and SG-Ⅱ） with different powder properties as absorbents,the adsorption kinetics model and isothermal curve model of paeonol were used to match the adsorption process,the adsorption quantity and adsorption rate of paeonol,along with the specific surface area,pore volume,pore size and other powder parameters,were taken as indexes to compare the adsorption capacity of these two kinds of calcium hydrogen phosphate. And the dissolution of paeonol from the two kinds of adsorptive dispersions was investigated. Result： Both of adsorbing processes of paeonol by SG-Ⅰ and SG-Ⅱ were in accordance with the pseudo secondary kinetic model,and the adsorption rate parameter of SG-Ⅱ（ 15. 832 g·g（-1）·h（-1）） was higher than that of SG-Ⅰ（ 8. 183 g·g（-1）·h（-1））.Within the selected concentration range of paeonol,its adsorbing processes by SG-Ⅰ and SG-Ⅱ were in agreement with Freundlich adsorption isothermal model. The adsorption quantity of paeonol by SG-Ⅱ（ 0. 926 g·g（-1）） was higher than that of SG-Ⅰ（ 0. 508 g·g（-1））. In two kinds of dissolution media,the desorption processes of the two kinds of adsorptive dispersions were accorded with the pseudo secondary kinetic model. The desorption rate of paeonol was similar between the two kinds of adsorptive dispersions in the same solvent. Conclusion： The adsorption property of SG-Ⅱ with larger specific surface area,pore volume and pore diameter is better than that of SG-Ⅰ. The desorption properties of SG-Ⅰ and SG-Ⅱ are similar.
作者
汤润曲
谢辉
吴逸晨
韩星星
唐婷婷
TANG Run-qu;XIE Hui;WU Yi-chen;HAN Xing-xing;TANG Ting-ting(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第21期26-31,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江苏高校品牌专业建设工程项目(PPZY2015A070)
江苏省大学生创新训练计划项目(201710315029Z)
关键词
磷酸氢钙
吸附
解吸附
丹皮酚
粉体学性质
等温吸附曲线
伪二级动力学模型
calcium hydrogen phosphate
adsorption
desorption
paeonol
powder properties
isothermal adsorption curve
pseudo secondary kinetic model
