摘要
目的探讨橄榄油联合多潘立酮治疗早产儿喂养不耐受的临床应用价值。方法选择医院2015年5月至2017年2月收治的喂养不耐受早产儿97例,按照随机数字表法分为对照组(48例)和研究组(49例)。对照组患儿给予多潘立酮治疗,研究组患儿在对照组基础上联合橄榄油治疗。所有患儿均治疗至全肠道喂养结束。结果研究组患儿的临床总有效率为93. 88%,显著高于对照组的72. 92%(χ~2=7. 734,P=0. 005);研究组患儿的住院时间、住院费用、呕吐停止时间、腹胀消失时间、喂养不耐受症状消失时间、达到全肠道喂养时间均明显低于对照组(P <0. 05),每日增加奶量和体质量增加显著高于对照组(P <0. 05);治疗期间,两组患儿的肝、肾功能正常,两组患儿不良反应的发生率比较无显著差异(χ~2=0. 177,P=0. 674)。结果橄榄油联合多潘立酮治疗早产儿喂养不耐受的临床疗效显著,可改善患儿的临床症状,且安全性高,值得临床推广。
Objective To investigate the clinical application value of olive oil combined with domperidone in the treatment of feeding intolerance in premature infants. Methods Totally 97 premature infants with feeding intolerance admitted to our hospital were selected and divided into the control group（48 cases） and the study group（49 cases） according to the random number table method. The control group was treated with domperidone, while the study group was treated with olive oil on the basis of the control group. All the children were treated until the end of total enteral feeding. Results The total effective rate of the study group was 93.88%, which was significantly higher than 72.92% of the control group（χ2 = 7. 734, P = 0. 005）. The hospitalization time, hospitalization expenses, stopping time of vomiting, disappearing time of abdominal distension, disappearing time of feeding intolerance and arrival time of total enteral feeding in the study group were significantly lower than those in the control group（P 〈 0. 05）, while the daily milk volume and body weight in the study group were significantly higher than those in the control group（P 〈 0.05）. During the treatment, the liver and kidney function of the two groups was normal, and there was no significant dift）rence in the incidence rate of adverse reactions between the two groups（χ2 =0. 177, P =0. 674）. Conclusion Olive oil combined with domperidone in the treatment of premature infants with feeding intolerance has significant clinical eft）ct, it can improve the clinical symptoms of infants, and has high safety, which is worthy of clinical promotion.
作者
涂娟娟
张丙宏
Tu Juanjuan;Zhang Binghong(Renmin Hospital of Wuhan University,Hubei General Hospital,Wuhan,Hubei,China 43006)
出处
《中国药业》
CAS
2018年第21期58-60,共3页
China Pharmaceuticals
基金
湖北省科技计划项目技术创新引导计划[2014CFA067]
关键词
橄榄油
多潘立酮
早产儿
喂养不耐受
临床疗效
olive oil
domperidone
premature infants
feeding intolerance
clinical effct
