摘要
目的观察吸入沙美特罗对慢性阻塞性肺疾病患者睡眠期动脉血氧饱和度和睡眠质量的影响。方法选择我院2015年1月～12月慢性阻塞性肺疾病患者60例,随机分为沙美特罗组和对照组,各30例。沙美特罗组接受吸入沙美特罗治疗,对照组接受安慰剂治疗。比较两组患者的SaO_2、睡眠质量指数和肺功能指标。结果治疗后,沙美特罗组睡眠期SaO_2为(93.03±7.43)%,对照组为(91.21±9.01)%,差异有统计学意义(P<0.05);且沙美特罗组睡眠期TST90为(2.40±0.4)%,对照组TST90为(19.53±1.72)%,差异有统计学意义(P<0.05)。治疗后,沙美特罗组患者肺功能较对照组改善,沙美特罗组FRC为(5.70±0.49)L,对照组为(6.23±0.54)L,差异有统计学意义(P<0.05);两组睡眠质量指数比较,差异无统计学意义(P>0.05)。结论吸入沙美特罗可改善COPD患者睡眠期SaO_2,对睡眠质量无显著影响。
Objective To observe the effect of inhaled salmeterol on arterial oxygen saturation and sleep quality in patients with chronic obstructive pulmonary disease during sleep.Methods 60 patients with chronic obstructive pulmonary disease from January to December 2015 in our hospital were randomly divided into salmeterol group and control group,30 cases each.The salmeterol group received inhaled salmeterol and the control group received placebo.SaO2,sleep quality index and lung function index were compared between the two groups.Results After treatment,the SaO2 in the salmeterol group was （93.03±7.43）%,the control group was （91.21±9.01）%,the difference was statistically significant （P〈0.05）;and the salmeterol group sleep period TST90 was （2.40±0.4）%,the control group TST90 was（19.53±1.72）%,the difference was statistically significant（P〈0.05）.After treatment,the lung function of the salmeterol group was improved compared with the control group,the FRC of the salmeterol group was （5.70±0.49）L,and the control group was （6.23±0.54）L,the difference was statistically significant （P〈0.05）;There was no significant difference in sleep quality index between the two groups （B〉0.05）.Conclusion Inhaled salmeterol can improve the sleep stage SaO2 in patients with COPD,and has no significant effect on sleep quality.
作者
陈晶
杜娟
牛学琴
李孔龙
柯亭羽
CHEN Jing;DU Juan;NIU Xue-qin;LI Kong-long;KE Ting-yu(Department of Endocrinology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan,China)
出处
《医学信息》
2018年第20期42-44,48,共4页
Journal of Medical Information
基金
国家自然科学基金资助项目(编号:81760327)
关键词
慢性阻塞性肺疾病
沙美特罗
动脉氧饱和度
睡眠质量
Chronic obstructive pulmonary disease
Salmeterol
Arterial oxygen saturation
Sleep quality
