摘要
目的探讨兰索拉唑对高血压脑出血(HICH)后应激性溃疡患者胃黏膜损伤及应激反应的影响。方法 HICH后应激性溃疡患者108例均分为两组。常规治疗基础上,试验组加用兰索拉唑30mg治疗,对照组加用奥美拉唑40mg治疗;兰索拉唑或奥美拉唑均加入0.9%氯化钠注射液100ml中静脉滴注,每日2次,治疗7d。比较两组临床疗效、应激反应及胃黏膜损伤等情况。结果试验组治疗总有效率高于对照组(88.89%vs.72.22%)(P<0.05)。治疗后,两组活性氧、丙二醛、黏着斑激酶、黏附连接相关蛋白纽蛋白、IL-2、表皮生长因子及pH值均较治疗前改善(P<0.05),且试验组优于对照组(P<0.05)。结论在常规治疗基础上,加用兰索拉唑治疗HICH后应激性溃疡较加用奥美拉唑效果更好。
Objective To investigate the effect of lansoprazole on gastric mucosal injury and stress response in the patients with stress ulcer（SU）after hypertensive intracerebral hemorrhage（HICH）.Methods A total of 108 SU patients after HICH was randomly divided into two groups with 54 cases each.Based on routine therapy,lansoprazole 30 mg（group L）or omeprazole 40 mg（group O）in 0.9% sodium chloride 100 ml was additionally infused twice a day for seven days.Clinical efficacy,stress response and gastric mucosal injury were compared between two groups.Results The overall effectiveness rate in group L was higher than that in group O（88.89% vs.72.22%）（P〈0.05）.After treatment,the levels of reactive oxygen species,malonic dialdehyde,focal adhesion kinase,vinculin,IL-2,epidermal growth factor and pH were improved in both groups（P〈0.05）,which were even better in group L than those in group O（P〈0.05）.Conclusion On the basis of conventional treatment,additionally use of lansoprazole has better efficacy in treating the patients with SU after HICH.
作者
叶峰
王晶
YE Feng;WANG Jing(Department of Neurology,Shaoxing Central Hospital,Shaoxing 312030,CHINA)
出处
《江苏医药》
CAS
2018年第9期1004-1007,共4页
Jiangsu Medical Journal
基金
浙江省医药卫生科技计划项目(20142DA017)
关键词
高血压脑出血
应激性溃疡
兰索拉唑
Hypertensive intracerebral hemorrhage
Stress ulcer
Lansoprazole
