摘要
目的探讨氢溴酸依他佐辛联合舒芬太尼对经尿道前列腺电切(TURP)患者术后镇痛的影响。方法选择择期全麻下行TURP患者120例,随机分为氢溴酸依他佐辛组(E组)、地佐辛联合舒芬太尼组(DS)、氢溴酸依他佐辛联合舒芬太尼组(ES组)(n=40)。术后采用患者自控镇痛(PCIA)。E组氢溴酸依他佐辛1 mg·kg^(-1); DS组地佐辛0.3 mg·kg^(-1)+舒芬太尼1.5μg·kg^(-1); ES组氢溴酸依他佐辛0.2 mg·kg^(-1)+舒芬太尼1.5μg·kg^(-1)。比较3组术后1 h(t_1)、4 h(t_2)、8 h(t_3)、12 h(t_4)、24 h(t_5)、48 h(t_6)视觉模拟评分(VAS)及Ramsay评分,记录术后48 h镇痛泵内药物总消耗量、镇痛药补救量及术后眩晕、恶心呕吐等不良反应发生率。结果与E组比较,DS组和ES组患者术后各时间点VAS评分均更低(P<0.05);且48 h镇痛泵药物总消耗量及镇痛药补救量均较少(P<0.05); DS组患者术后眩晕、恶心呕吐、躁动及嗜睡发生率较E组高(P<0.05); ES组患者恶心呕吐发生率较E组高(P<0.05)。与DS组比较,ES组患者术后各时点VAS评分差异无统计学意义(P>0.05),术后48 h镇痛泵药物总消耗量及补救药需要量更少(P<0.05),术后呼吸抑制、眩晕、躁动及嗜睡发生率更低(P<0.05)。3组术后各时间点Ramsay评分差异无统计学意义(P>0.05)。结论氢溴酸依他佐辛联合舒芬太尼能够有效缓解TURP患者术后疼痛,减少患者术后镇痛药使用量及镇痛相关不良反应。
Objective To explore effect of eptazocine hydrobromide combined with sufentanil on postoperative analgesia after trans-urethral resection prostate （TURP）.Methods One hundred and twenty adult patients undergoing TURP were randomly divided into three groups （ n =40）：eptazocine hydrobromide group （group E）, dezocine combined with sufentanyl group （group DS） and eptazocine hydrobromide combined with sufentanyl group （group ES）.All patients received postoperative patient controlled intravenous analgesia （PCIA）.The patients in the group E were given eptazocine hydrobromide with dose of 1 mg·kg -1 ;group DS patients were given with dezocine of 0.3 mg·kg -1 combined with sufentanil 1.5 μg·kg -1 ;group ES patients were given eptazocine hydrobromide 0.2 mg·kg -1 combined with sufentanil 1.5 μg·kg -1 .The VAS scores and Ramsay scores were recorded at 1 h （t 1 ）, 4 h （t 2 ）,8 h （t 3 ）, 12 h （t 4 ）, 24 h （t 5 ） and 48 h （t 6 ） postoperatively.Total analgesic consumption of PCIA pump and total need of remedial drugs, the incidences of postoperative dizziness, nausea and vomiting, and other adverse reactions during postoperative 48 h were also documented.Results Compared with group E, VAS scores at each time point postoperatively in group DS and group ES were lower （ P 〈0.05）;and total analgesic consumption of PCIA pump and total need of remedial drugs were also lower than group E（ P 〈0.05）;the incidence of vertigo, nausea and vomiting, dysphoria, drowsiness in group DS were higher（ P 〈0.05）;while only the incidence of nausea and vomiting in group ES was higher than group E （ P 〈0.05）.Compared with group DS, no statistical significances of VAS scores were found at each time point postoperatively between group DS and group ES （ P 〉0.05）;but total analgesic consumption of PCIA pump and the need of remedial drugs in group ES were lower （ P 〈0.05）;patients in group ES with lower incidence of respiratory depression, vertigo, dysphoria and drowsiness （ P 〈0.05）.No statistical significances were found when comparing the Ramsay scores at each time point postoperatively among three groups （ P 〉0.05）.Conclusion Eptazocine hydrobromide combined with sufentanyl can effectively alleviate the postoperative pain in patients with TURP, reduce the consumption of postoperative analgesics and incidence of analgesic related adverse reactions.
作者
甘建辉
涂青
GAN Jianhui;TU Qing(Department of Anesthesiology,the Affiliated Tangshan People＇s Hospital, North China University of Science and Technology, Tangshan 063000, China)
出处
《医药导报》
CAS
北大核心
2018年第11期1348-1351,共4页
Herald of Medicine
关键词
依他佐辛
氢溴酸
地佐辛
舒芬太尼
经尿道前列腺电切术
镇痛
术后
Eptazocine,hydrobromide；Dezocine；Sufentanyl；Trans-urethral resection prostate；Analgesia
postoperative
