摘要
目的:分析中医治疗睾丸微石症致男性不育的效果及相关机制。方法:将45例睾丸微石症致男性不育患者给予自拟聚精助育汤治疗,连续治疗6个月,期间正常同房,观察配偶妊娠情况,对比治疗前后睾丸血流、液化时间、精子密度、畸形精子比例、精子活力等变化。结果:治疗后随访1年,患者配偶妊娠35例,妊娠成功率为77.78%。与治疗前相比,治疗后患者双侧睾丸血流阻力指数(resistance index,RI)下降,睾丸收缩期峰值血流速度(peak systolic velocity of testicular systolic blood flow,PSV)升高,差异有统计学意义(P<0.05)。与治疗前相比,治疗后患者的精液液化时间缩短、精子密度升高、畸形精子比例下降,差异有统计学意义(P<0.05)。与治疗前相比,治疗后前向运动精子率(Forward motility spermatozoon rate,PR)升高,非前向运动精子率(Non forward motility sperm rate,NP)升高、不活动精子率(Inactive sperm rate,IM)下降,差异有统计学意义(P<0.05)。与治疗前相比,治疗后阳痿早泄、神疲乏力、腰膝酸软等症状积分下降,差异有统计学意义(P<0.05)。结论:采用聚精助育汤治疗睾丸微石症致男性不育的效果确切,增加睾丸血流、改善精子质量是其治疗男性不育的作用机制之一。
Objective：To analyze the effect and mechanism of TCM treatment of male infertility caused by testicular microlithiasis. Methods ： Forty-five cases of male infertility caused by testicular microlithiasis were treated with self-made Jujing Zhuyu Decoction for 6 months. During normal treatment, the pregnancy of the spouse was observed. The testicular blood flow and liquefaction time, changes in sperm density, abnormal sperm ratio, and sperm motility were compared before and after treatment. Results：After 1 year treatment,35 patients were diagnosed and the pregnancy success rate was 77.78%. Compared with that before treatment, the pa- tient＇s testieular blood flow resistance index （RI） decreased and the peak systohc velocity of testicuiar systolic blood flow （PSV） increased after treatment. There were significant statistics differences （P 〈 0.05 ）. Compared with that before treatment, the semen liquefaction time was shortened, the sperm density increased, and the proportion of abnormal sperm decreased after treatment, and there was a statistically significant difference （P 〈 0.05 ）. Compared with that before treatment ,the forward motility spermatozoon rate （PR） increased,the non-forward motility sperm rate （NP） increased, and the inactive sperm rate （IM） decreased,and there was a significant statistical difference （ P 〈 0.05 ）. Compared with that before treatment, the scores of symptoms such as impo- tence, premature ejaculation,fatigue, and waist and knees decreased after treatment, and there was a statistically significant differ- ence （P 〈 0.05 ）. Conclusion ： The use of Jujing Zhuyu Decoction in treatment of male infertility caused by testicular microlithiasis is effective. One of the mechanisms of that may be the increasing of the testicular blood flow and improving of the sperm quality.
作者
王炎
WANG Yan(Maternal and Child Health Care Hospital of Xinxiang City,Xinxiang Henan China 45300)
出处
《中医学报》
CAS
2018年第9期1763-1766,共4页
Acta Chinese Medicine
关键词
睾丸微石症
男性不育
聚精助育汤
中医药治疗
testicular microlithiasis
male infertility
Jujing Zhuyu Decoction
traditional Chinese medicine treatment
