摘要
目的探讨辛伐他汀预防高血压脑出血微创手术后下肢深静脉血栓的效果。方法选取自2015年3月至2016年12月收治的86例高血压脑出血患者为研究对象,按随机数字表法分为A组与B组,每组各43例。A组患者采取常规的下肢深静脉血栓预防措施,B组患者在A组的基础上服辛伐他汀20 mg,1次/d。治疗3个月后,观察两组患者的治疗效果、下肢周径差及下肢深静脉血栓的发生率。结果 A组患者治疗显效24例,有效15例,无效4例; B组患者治疗显效35例,有效7例,无效1例,B组患者的显效率为81. 4%(35/43),显著高于A组的55. 8%(24/43),差异有统计学意义(P <0. 05)。A组患者的下肢深静脉血栓发生率为39. 5%(17/43),显著高于B组的11. 6%(15/43),差异有统计学意义(P <0. 05)。治疗后,A组患者髌骨上15 cm的周径差为(3. 68±1. 86) cm,显著高于B组的(2. 93±1. 67) cm,差异有统计学意义(P <0. 05)。治疗后,A组患者髌骨下15 cm的周径差为(4. 16±1. 71) cm,显著高于B组的(3. 08±1. 62) cm,差异有统计学意义(P <0. 05)。结论辛伐他汀能有效预防高血压脑出血患者术后下肢深静脉血栓的形成,减轻下肢肿胀,可安全、有效地提高治疗显效率。
Objective To investigate the effect of simvastatin on the prevention of deep venous thrombosis of the lower extremities after minimally invasive surgery for hypertensive intracerebral hemorrhage. Methods A retrospective study was performed on 86 cases of patients with hypertensive intracerebral hemorrhage who were admitted from March 2015 to December 2016. Patients were randomly divided into the Group A and Group B,with 43 cases in each group. Patients in the Group A were given conventional lower extremity deep venous thrombosis prevention measures,the others in Group B took simvastatin at 20 mg,1 time/day on the basis of Group A. After 3 months of treatment,the therapeutic effect,the peripheral diameter difference of lower limbs and the incidence of deep venous thrombosis in lower limbs were observed. Results In Group A,there were excellent in 24 cases,effective in 15 cases and ineffective in 4 cases; in Group B,there were excellent in 35 cases,effective in 7 cases and ineffective in 1 case. The effective rate in Group B was81. 4%（ 35/43）,which was significantly higher than 55. 8%（ 24/43） in Group A,and the difference was statistically significant（ P 0. 05）. The incidence of deep venous thrombosis of lower extremities in Group A was 39. 5%（ 17/43）,which was significantly higher than 11. 6%（ 15/43） of Group B（ P〈 0. 05）. After treatment,the diameter difference of 15 cm above patella of Group A was（ 3. 68 ±1. 86） cm,which was significantly higher than（ 2. 93 ± 1. 67） cm of Group B（ P〈 0. 05）. After treatment,the diameter difference of15 cm below patella of Group A was（ 4. 16 ± 1. 71） cm,which was significantly higher than（ 3. 08 ± 1. 62） cm（ P〈 0. 05）. Conclusion Simvastatin can effectively prevent the formation of deep vein thrombosis in patients with hypertensive intracerebral hemorrhage,reduce the degree of lower extremity swelling,and effectively improve the effective rate of treatment.
作者
刘强
宋平
LIU Qiang;SONG Ping(Department of Surgery,Luzhou Maternal and Child Health Care Hospital,Luzhou 646699,China)
出处
《创伤与急危重病医学》
2018年第5期279-280,282,共3页
Trauma and Critical Care Medicine
关键词
辛伐他汀
高血压脑出血
下肢深静脉血栓
显效
Simvastatin
Hypertensive cerebral hemorrhage
Lower extremity deep venous thrombosis
Excellent
