摘要
目的探讨水通道蛋白1(APQ1)、乙肝病毒基因X开放读框编码的乙肝病毒X蛋白(HBx)在乙肝相关性肝癌组织中的表达及其临床病理学意义。方法选取我院手术后肝癌组织标本80例(病灶组)、40例癌旁组织(癌旁组),收集时间2015年1月-2017年6月,检测两组标本中的APQ1、HBx蛋白,并分析其与患者临床病理学特征的关系。结果病灶组的APQ1、HBx蛋白表达阳性率分别为71.25%、68.75%均显著高于癌旁组5.00%、10.00%(P<0.05);肝癌组织中APQ1蛋白表达与患者TNM分期、发生淋巴结转移、肿瘤分化程度具有显著相关性(P<0.05);肝癌组织中HBx蛋白表达阳性率与肿瘤发生门脉侵袭、TNM分期、发生淋巴结转移具有显著相关性(P<0.05)。结论 APQ1、HBx蛋白在乙肝相关性肝癌组织中高表达,并且与肿瘤的发生发展关系密切。
Objective To investigate the expression of hepatitis B virus X protein（HBx） encoded by open reading frame of aquaporin 1（APQ1） and hepatitis B virus gene（X） in hepatitis B virus associated hepatocellular carcinoma（HCC） and its clinicopathological significance. Methods Eighty cases of hepatocellular carcinoma（lesion group） and 40 cases of para cancerous tissue（cancer adjacent group） were selected from our hospital from January 2015 to June 2017. The APQ1 and HBx protein in two groups were detected,and the relationship between the two groups and clinicopathological features was analyzed. Results The protein positive rate of APQ1,HBx in lesion group was 71.25%,68.75%,were significantly higher than that in the adjacent group5%,10%（P0.05）;APQ1 protein in patients with TNM staging,lymph node metastasis,tumor differentiation has a significant correlation between the expression of hepatocellular carcinoma（P〈0.05）;the positive rate of tumor and portal vein invasion,TNM staging,lymph node metastasis has significant correlation between the expression of HBx protein in hepatocellular carcinoma（P〈0.05）.Conclusion APQ1 and HBx protein are highly expressed in hepatitis B related liver cancer tissues,and closely related to the occurrence and development of tumors.
作者
雷阳
李跃文
LEI Yang1,LI Yuewen2(1.Department of clinical laboratory ,Xinyang Central Hospital ,He nan ,Xinyang , 464000 ; 2.Departme nt of clinical laboratory, Zhumadian first people＇s Hospital ,He nan ,Zhumadian, 46300)
出处
《实验与检验医学》
CAS
2018年第5期685-688,共4页
Experimental and Laboratory Medicine
关键词
水通道蛋白1
HBX
乙肝
肝癌
Aquaporin 1
HBx
hepatitis B related hepatocellular carcinoma
