摘要
目的探讨维持性血液透析患者血红蛋白变异与心脑血管事件的关联。方法方便选取2015年1月—2018年4月就诊于该院行维持性血液透析治疗的86例患者作为研究对象,根据血红蛋白变异是否发生变异将86例患者分为实验组(发生变异组,36例)和对照组(未发生变异组,50例),监测两组患者血红蛋白指标,记录心脑血管事件发生率,分析血红蛋白变异与心脑血管事件的关联。结果基础血红蛋白水平比较实验组(120.33±5.48)g/L明显高于对照组(102.74±3.82)g/L(t=16.021,P=0.000);铁蛋白水平比较实验组(289.71±42.30)ng/m L明显低于对照组(340.47±54.37)ng/m L(t=4.333,P=0.000);EPO使用剂量比较,实验组明显高于对照组(P<0.05);维持血液透析期间两组患者心脑血管事件发生率比较,实验组(134.86±51.01)IU/(kg·W)明显高于对照组(114.34±30.84)IU/(kg·W)(t=2.110,P=0.039);因心脑血管事件住院概率比较,实验组(30.56%)也明显高于对照组(4.00%)(χ2=27.293,P=0.000)。结论维持性血液透析患者血红蛋白变异越频繁,发生心脑血管事件的概率越高,两者呈正相关,积极控制血红蛋白水平对提升血液透析患者预后意义重大,值得推广。
Objective To investigate the association between hemoglobin variation and cardiovascular and cerebrovascularevents in maintenance hemodialysis patients. Methods 86 patients who underwent maintenance hemodialysis in the hospitalfrom January 2015 to April 2018 were convenient selected as study subjects. 86 patients were divided into experimentalgroups according to whether hemoglobin variation was mutated or not （mutation group, 36 cases）, and the control group （nomutation group and 50 cases）, hemoglobin indicators were monitored in two groups, and the incidence of cardiovascular andcerebrovascular events was recorded. The association between hemoglobin variation and cardiovascular and cerebrovascularevents was analyzed. Results The basal hemoglobin level was significantly higher in the experimental group （120.33±5.48） g/Lthan in the control group （102.74±3.82） g/L （t=16.021, P=0.000）; the ferritin level was compared to the experimental group（289.71±42.30） ng /mL was significantly lower than that of the control group （340.47±54.37） ng/mL （t=4.333, P=0.000）; thedose of EPO was significantly higher in the experimental group than in the control group （P〈0.05）; both groups were maintained during maintenance hemodialysis, incidence of cardiovascular and cerebrovascular events was significantly higher inthe experimental group （134.86±51.01） IU/（kg·W） than in the control group （114.34±30.84） IU/（kg·W）（t=2.110, P=0.039）; hospitalization due to cardiovascular and cerebrovascular events. Compared with the probability, the experimentalgroup （30.56%） was also significantly higher than the control group （4.00%） （X^2=27.293, P=0.000）. Conclusion The morehemoglobin variation in maintenance hemodialysis patients, the higher the probability of occurrence of cardiovascular andcerebrovascular events and the positive correlation between the two. Active control of hemoglobin levels is of great significance in improving the prognosis of hemodialysis patients and is worthy of promotion.
作者
李侠
LI Xia(Department of Nephrology,Fengxian County People＇s Hospital,Fengxian,Jiangsu Province,217000 China)
出处
《中外医疗》
2018年第24期82-83,89,共3页
China & Foreign Medical Treatment
关键词
维持性血液透析
血红蛋白变异
心脑血管事件
Maintenance hemodialysis
Hemoglobin variation
Cardio-cerebral vascular events
