摘要
目的探讨c－kit mRNA的表达与直肠癌患者术后预后的关系。方法采用分支DNA液相芯片法检测66例直肠癌患者肿瘤组织中c－kit mRNA的表达情况，根据表达结果将患者分为c－kit mRNA低表达组和高表达组，分析c－kit mRNA的表达情况与患者临床病理特征的关系以及影响患者预后的因素。结果66例直肠癌患者中，c－kit mRNA高表达18例（27.3%），c－kit mRNA在直肠癌组织中的表达与患者的性别、年龄、术前癌胚抗原（CEA）水平、术前血红蛋白水平、肿瘤距肛缘距离、分化程度、淋巴结转移、脉管癌栓、T分期以及TNM分期均无关（均P〉0.05）。至随访结束，66例患者中，死亡34例，生存32例，复发转移36例。c－kit mRNA高表达组患者的1、3、5年生存率分别为100%、77.8%和77.8%，c－kit mRNA低表达组患者的1、3、5年生存率分别为93.8%、56.3%和45.8%，组间差异有统计学意义（P＝0.025）。淋巴结转移、T分期、TNM分期也与患者的总生存有关（均P〈0.05）。c－kit mRNA高表达组患者的1、3、5年无病生存率分别为100%、77.8%和77.8%，c－kit mRNA低表达组患者的1、3、5年无病生存率分别为77.1%、43.8%和41.7%，组间差异有统计学意义（P＝0.044）。c－kit mRNA的表达（P＝0.038）和TNM分期（P＝0.039）是影响直肠癌患者总生存的独立因素。结论c－kit低表达与直肠癌的不良预后有关，其影响直肠癌患者预后的机制值得进一步探究。
Objective To investigate the correlation between c-kit mRNA expression and prognosis in patients with rectal carcinoma. Methods The expression of c-kit mRNA in rectal carcinoma tissues（n = 66） was detected by multiplex branched-DNA liquid chip method. According to the expression level, the patients were classified into the c-kit mRNA high expression group and the low group. We analyzed the relationship between the c-kit mRNA expression and the clinicopathological characteristics of patients, as well as the factors affecting patients＇prognosis. Results Of the 66 rectal carcinoma patients, 18 （27.3%） cases were c-kit mRNA high expression. No significant correlation was found between the c-kit mRNA expression and gender, age, preoperative carcinoembryonic antigen, preoperative hemoglobin, distance to verge, lymph node metastasis, tumor thrombus, T stage, TNM stage and tumor differentiation （P〉0.05）. In follow-up, 34 patients died, 32 patients and 36 patients were recurrence or metastasis. The 1-, 3-, 5-year overall survival（OS） of c-kit mRNA high expression group were 100.0%, 77.8%, 77.8%, respectively, while those of the low one were 93.8%, 56.3%, 45.8%, respectively. The difference was statistically significant（ P= 0.025）. Lymph node metastasis, T stage and TNM stage were also significant associated with OS（P〈0.05）. The 1-, 3-, 5-year disease free rate （DFS）of the c-kit mRNA high expression group were 100.0%,77.8% and 77.8%, respectively, while those of the low one were 77.1%,43.8% and 41.7%, respectively, and the difference between the two groups was significant （ P = 0.044）. As a reslut, c-kit mRNA expression （P= 0.038） and TNM stage （P= 0.039） were the independent prognostic factors affecting the OS in rectal cancer patients. Conclusions Low expression of c-kit was associated with poor prognosis of rectal carcinoma. And the mechanism underlying this phenomenon deserves further exploration.
作者
林延宗
黄云霞
应敏刚
孔祥泉
林凤村
Lin Yanzong;Huang Yunxia;Ying Mingang;Kong Xiangquan;Lin Fengcun(Department of Gastrointestinal Surgical Oncology,Fujian Medical University Cancer Hospital,Fuzhou 350014,China（Lin YZ,Ying MG;Department of Abdominal Radiation Oncology,Fufian Medical University Cancer Hospital,Fuzhou 350014,China（Huang YX,Kong XQ;Department of Radiation Oncology,Zhangzhou Hospital Affiliated to Fujian Medical University,Zhangzhou 363000,China（Lin FC)
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2018年第9期667-671,共5页
Chinese Journal of Oncology
