摘要
目的:探讨托吡酯在偏头痛患者中的临床效果及对神经元放电和脑血流的影响。方法:选取2015年5月至2018年1月曹县人民医院收治的偏头痛患者100例,根据治疗方案分为对照组和观察组,每组50例。比较2组治疗前和治疗后2个月头痛发作、持续时间和头痛评分。结果:通过比较2组治疗后头痛发作、持续时间及头痛评分均少(短)于治疗前(P<0.05);观察组治疗后2个月头痛发作、持续时间及头痛评分,均少(短)于对照组(P<0.05);观察组与对照组脑蛋白变性发生率差异无统计学意义(P>0.05);观察组α波频率降低、δ波增多及θ波增多率,均高于对照组(P<0.05);观察组治疗后3个月椎动脉、基底动脉、大脑前动脉、中中脉及后动脉血流速度,均高于对照组(P<0.05)。结论:将托吡酯用于偏头痛患者中有助于减少偏头痛发作次数,改善神经元放电及脑血流速度,值得推广应用。
Objective： To explore the clinical effect of topiramate in migraine patients and its effect on neuron discharge and cerebral blood flow. Methods： One hundred patients with migraine were enrolled in the hospital in January-2018 May 2015.According to the treatment scheme,the patients were divided into the control group （ n =50 cases） and the observation group （ n =50 cases）. Results： The headache attack,duration and headache score of the observation group and the control group were less than before the treatment （ P 〈0.05）.The headache attack,duration and headache score of the observation group were less than that of the control group （ P 〈0.05） after the treatment （ P 〈0.05）,and the incidence of brain protein degeneration was not statistically significant in the observation group and the control group（ P 〈0.05）.The study significance （ P 〉0.05） was higher than that of the control group （ P 〈0.05）.The blood flow velocity of vertebral artery,basilar artery,anterior cerebral artery,middle middle vein and posterior artery in the observation group was higher than that of the control group （ P 〈0.05） after 3 months of treatment. Conclusion： Topiramate in migraine patients is helpful to reduce the number of migraine attacks,improve neuron discharge and cerebral blood flow velocity,and is worthy of popularization and application.
作者
谭相如
Tan Xiangru(Caoxian people′s Hospital of Shandong province,Caoxian,27440)
出处
《世界睡眠医学杂志》
2018年第6期625-627,共3页
World Journal of Sleep Medicine
