摘要
目的探讨氨溴索辅助治疗成人重症肺炎疗效及其对肺功能指标、炎性因子的影响。方法选取该院2015年1月—2017年1月收治的80例重症肺炎患者研究对象,根据不同治疗方式分为两组,观察组40例患者给予氨溴索辅助治疗,对照组40例患者给予常规治疗,对比两组患者肺功能指标以及炎性介质水平。结果治疗后观察组患者PEF、MMF、FEV1/FVC、FEV1、FVC分别为(7.52±0.53)L/s、(3.05±0.57)L、(74.46±8.11)%、(2.99±0.30)L、(3.03±0.48)L,明显高于对照组(6.37±0.46)L/s、(2.13±0.45)L、65.27±8.16)%、2.27±0.37)L、(2.64±0.59)L,差异有统计学意义(t=10.363 9、8.012 1、5.052 1、9.559 7、3.243 0,P<0.05)。治疗后观察组患者PCT、IL-8、IL-6、TNF-、hs-CRP水平分别为(1.27±0.21)ng/mL、(218.94±14.22)pg/mL、(19.86±1.73)pg/mL、(37.99±3.94)ng/mL、(11.65±1.06)pg/mL,明显低于对照组(2.62±0.30)ng/mL、(339.69±12.64)pg/mL、(23.52±2.44)pg/mL、(43.44±4.74)ng/mL、(14.29±1.74)pg/mL,差异有统计学意义(t=23.315 7、40.139 9、7.739 0、5.592 2、8.195 0,P<0.05)。结论氨溴索辅助治疗成人重症肺炎疗效显著,可有效改善肺功能、炎症反应,且安全性高,值得临床推广。
Objective To study the effect of ambroxol assisted therapy on the lung function indicators and inflammatory factors of adult patients with severe pneumonia. Methods 80 cases of patients with severe pneumonia admitted and treated in our hospital from January 2015 to January 2017 were selected as the research objects and divided into two groups with 40 cases in each, according to different treatment ways, the observation group used the ambroxol assisted therapy, while the control group used the routine therapy, and the lung function indicators and inflammatory mediator level were compared between the two groups. Results After treatment, the PEF, MMF, FEV1/FVC, FEV1, FVC in the observation group were obviously higher than those in the control group [（7.52 ±0.53）L/s,（3.05 ±0.57）L,（74.46 ±8.11）%,（2.99±0.30）L,（3.03±0.48）L vs（6.37±0.46）L/s,（2.13±0.45）L,（65.27±8.16）%,（2.27±0.37）L,（2.64±0.59）L], and the differences were statically significant,（t=10.363 9, 8.012 1, 5.052 1, 9.559 7, 3.243 0, P〈0.05）, after treatment, the PCT, IL-8, IL-6,TNF-, hs-CRP levels in the observation group were obviously lower than those in the control group, [（1.27±0.21）ng/mL,（218.94±14.22）pg/mL,（19.86±1.73）pg/mL,（37.99±3.9）ng/mL,（11.65±1.06）pg/mL vs（2.62±0.30）ng/mL,（339.69±12.64）pg/mL,（23.52±2.44）pg/mL,（43.44±4.74）ng/mL,（14.29±1.74）pg/mL], and the differences were statistically significant（t=23.3157, 40.139 9, 7.739 0, 5.592 2, 8.195 0, P〈0.05）. Conclusion The curative effect of ambroxol assisted therapy of adult patients with severe pneumonia can effectively improve the lung function and inflammation reactions with high safety,and it is worth clinical promotion.
作者
刘守军
李庆峰
LIU Shou-jun;LI Qing-feng(Department of Emergency,Shenxian Second People＇s Hospital,Shenxian,Shandong Province,252423 China;Hemodialysis Room,Shenxian Second People＇s Hospital,Shenxian,Shandong Province,252423 China)
出处
《系统医学》
2018年第13期53-54,63,共3页
Systems Medicine
关键词
氨溴索
成人
重症肺炎
肺功能
炎性因子
影响
Ambroxol
Adult
Severe pneumonia
Lungfunction
hfflammatory factor
Effect
