摘要
目的分析儿童过敏性紫癜继发肾损伤检测中纤维蛋白原(FIB)、D-二聚体(D-D)和纤维蛋白原降解物(FDP)的表达及意义。方法选择2016年6月至2018年6月本院30例过敏紫癜患儿,按照是否出现肾损伤将其分为15例紫癜性肾炎(HSPN)组和15例普通型过敏紫癜(HSP)组,检测两组儿童24 h尿蛋白排泄量、血肌酐等HSP肾损伤指标,并比较血FIB、D-D和FDP纤溶指标的水平变化。结果 HSPN组24 h尿白定量显著高于HSP组,差异具有统计学意义(P<0.01)。与HSP组相比,HSPN组血肌酐水平显著升高(P<0.05)。两组患者FIB(≥4 g/L即为阳性)、D-D(≥0.3 g/L即为阳性)和FDP(≥3 g/L即为阳性)水平均表现为阳性结果。与HSP组相比,HSPN组FIB、D-D和FDP水平均有显著升高,差异有统计学意义(P<0.01)。结论 HSPN患儿疾病活动期存在凝血、纤溶系统异常,继发性纤溶可能参与本病的肾损伤过程,但其确切机制有待进一步研究。
Objective To investigate the expression and clinical significance of fibrinogen（FIB）,D-two（D-D）and fibrinogen degradation（FDP）in children with Henoch Schonlein purpura secondary renal damage.Methods June 2016 ～ June 2018 in our hospital 30 cases of allergic purpura,according to whether the renal damage can be divided into 15 cases of Henoch Schonlein purpura nephritis（HSPN group）,15 cases of common type allergic purpura（HSP group）,detection of urinary protein excretion in two groups of children 24 h,serum creatinine and HSP renal damage index,change level and compare the blood FIB,D-D and FDP fibrinolysis.Results HSPN group 24 h urine quantitative was significantly higher than that of HSP group,the difference was statistically significant（P〈0.01）.In addition,serum creatinine levels were significantly higher in group HSPN than in group HSP（P〈0.05）.Two groups of patients（FIB≥4 g/L is positive）,D-D（0.3 g/L is positive）and FDP（≥3 g/L is positive）levels showed positive results.Compared with the HSP group,the levels of FIB,D-D and FDP in the HSPN group were significantly increased,the difference was statistically significant（P〈0.01）.Conclusion There is abnormal coagulation and fibrinolysis in the active period of HSPN,and secondary fibrinolysis may be involved in this disease.The mechanism of renal injury,but the exact mechanism remains to be further studied.
作者
张颖辉
孙小莉
冯国仙
崔丽娟
Zhang Yinghui;Sun Xiaoli;Feng Guoxian;Cui Lijuan(Guangzhou Baiyun District Maternal and Child Health Care Hospital,Guangzhou 510410,China)
出处
《哈尔滨医药》
2018年第4期336-337,共2页
Harbin Medical Journal
基金
广州市白云区科技计划项目<儿童紫癜性肾炎凝血与纤溶系统变化与肾损伤的关系>(2016-KZ-043)
