Notch4和DLL4在早发型重度子痫前期中的表达及临床意义被引量：2

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摘要目的探讨Notch4、DLL4在早发型重度子痫前期发生中的作用机制。方法选取2015年6月-2016年6月该院收治的30例早发型重度子痫前期患者为研究组,正常足月孕妇30例为对照组,以免疫组化法检测胎盘组织中Notch4、DLL4的表达部位,以实时荧光定量PCR和Western blot检测胎盘中Notch4、DLL4 mRNA和蛋白的表达水平。结果 Notch4、DLL4主要表达于胎盘血管内皮细胞胞核。与对照组相比,研究组Notch4、DLL4 mRNA和蛋白的表达下调(P<0.0 5)。结论在早发型重度子痫前期患者中,胎盘组织中的Notch4、DLL4蛋白表达均下调,推测Notch信号通路尤其是Notch4、DLL4可能与该病的发生发展有关。

作者余晖张丽陈丹玲温济英刘国成

机构地区广东省妇幼保健院产科

出处《中国妇幼保健》 CAS 2018年第17期4013-4015,共3页 Maternal and Child Health Care of China

基金广东省科技计划项目(2014A020212548)

关键词重度子痫前期 NOTCH4 DLL4 滋养细胞

分类号 R737.14 [医药卫生—肿瘤]

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