摘要
抑郁症是一种常见的精神疾病,有高患病率、高复发率和高致死率等特点,受到国际社会的广泛关注,迫切需要对其发病机制及有效治疗手段开展研究。经颅磁刺激(TMS)是一种新型的物理治疗技术,因其有非侵入、安全、有效的优势,在抑郁症治疗中已日益显现出潜在的应用前景。虽然临床研究已证实该项技术的治疗有效性,但对其刺激参数优化选择和作用机理的全面了解仍需前期进行大量的抑郁模型动物基础性实验研究。从刺激参数和作用机制两个方面回顾近些年TMS作用于抑郁模型动物实验研究的主要进展,归纳其尚存在的问题并展望今后可能的发展前景,以期促进TMS技术治疗抑郁症的深入研究。
Depression is a common mental illness that has aroused general concerns. The depression has the characteristics of high prevalence,high recurrence rate and high mortality. It＇s important and of significanceto study the pathogenesis and effective treatment approches. As a non-invasive,safe and effective method,transcranial magnetic stimulation（ TMS） has superiority in treating the depression. Although many clinical studies have proven its effectiveness,basic experimental studies on the animal model are still needed for fully insight into the optimal selection of stimulus parameters and its mechanism. Here we reviewed the research of the effects of TMS on depression rat model in recent years from two aspects： stimulus parameters and the underlying mechanisms. This paper discussed some major problems and future prospects of the research on TMS treating depression rat model in order to promote the development and application of TMS.
作者
王玲
杨佳佳
王发颀
万柏坤
明东
Wang Ling;Yang Jiajia;Wang Faqi;Wan Baikun;Ming Dong(School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,China)
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
2018年第4期498-507,共10页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金青年项目(3100865)
国家自然基金重点项目(81630051)
关键词
经颅磁刺激
抑郁症
动物模型
刺激参数
作用机制
transcranial magnetic stimulation （TMS）
depression
animal model
stimulus parameter
mechanism of action
