摘要
The interfacing study of biopolymer and supramolecular chemistry enables a better understanding of fundamental biochemical processes and the creating of new high-performance biomaterials. In this review, we introduced an "in vivo self-assembly" strategy which means in situ construction of functional self-assembled superstructures in specific physiological or pathological conditions in cell, tissue or animal levels that exhibit diverse biomedical effects. By using this strategy, unexpected phenomena and insights, e.g, assembly/aggregation induced retention (AIR) effect have been demonstrated where the self-assembled nanostructures showed extraordinary enhanced accumulation and retention of therapeutics in targeted sites.
基金
financially supported by the National Natural Science Foundation of China(Nos.21704020,21374026,and51573032)
the National Science Fund for Distinguished Young Scholars(No.51725302)
financial support from the China Postdoctoral Science Foundation(No.2017M620707)
