摘要
目的:探讨神经生长因子辅助治疗新生儿缺氧缺血性脑病临床效果。方法:选取某院收治的新生儿缺氧缺血性脑病患儿104例,利用随机数表法分为2组,每组各52例。对照组采取胞磷胆碱与脑蛋白水解物进行治疗,观察组在此基础上加用神经生长因子进行治疗,比较2组患儿临床疗效、神经行为发育指标(NPY,NSE,MBP)、血清肌酸激酶(CK)水平、脑型同工酶水平(CK-BB)、肌酸激酶同工酶(CK-MB)、神经行为功能评分及神经系统后遗症。结果:2组患儿治疗总有效率比较,观察组(94.23%)较对照组(80.77%)高,差异有统计学意义(P<0.05);治疗后,2组患儿NPY,NSE,MBP,CK,CK-MB,CK-BB水平均显著降低,且观察组较对照组低,差异有统计学意义(P<0.05);治疗第7天、第14天,2组患儿NBFS评分均明显提高,且观察组优于对照组,差异有统计学意义(P<0.05);2组后遗症发生率比较,观察组(7.69%)较对照组(23.08%)低,2组比较差异有统计学意义(P<0.05)。结论:神经生长因子联合胞鳞胆碱及脑蛋白水解物治疗,可有效改善缺氧缺血性脑病患儿神经行为功能,降低神经系统后遗症发生率。
Objective ：To investigate the clinical effect of nerve growth factor （NGF） in treatment of neonatal hypoxic-ischemic en- cephalopathy （ HIE ）. Methods ：104 HIE children were randomly divided into two groups, 52 cases in each. The control group was giv- en citieoline and cerebroprotein hydrolysate, while the observation group was treated with NGF based on the regime of the control group. The clinical efficacy, neurobehavioral development indexes （ NPY, NSE, MBP ）, serum creatine kinase （ CK ）, creatine kinase （CK-BB） ,creatine kinase isoenzyme （ CK-MB）, neurobehavioral function scores,and neurological sequelae were compared between the two groups. Results ：The total effective rate of the observation group （94.23%） was higher than that of the control group （80.77% ,P 〈 0.05 ）. After the treatment, the levels of NPY, NSE, MBP, CK, CK-MB, and CK-BB in the two groups deereased, lower in the ob- se^wation group than in the control group （ P 〈 0.05 ）. 7d and 14d after the treatment, the neurobehavioral functional scale （ NBFS ） of the two groups increased, with the observation groupg scale being higher than the control groupg （P 〈 0.05 ）. The incidence of sequelae in the observation group （7.69%） was lower than that in the control group （ 23.08%, P 〈 0.05 ）. Conclusion ： NGF combined with citicoline and cerebroprotein hydrolysate in treatment of HIE is effective. It can improve neurobehavioral function and deerease the inci- dence of neurological sequelae.
作者
张秀梅
ZHANG Xiu-mei(Department of Pediatrics,The People＇s Hospital of Dengzhou City,Henan 474150,China)
出处
《淮海医药》
CAS
2018年第5期543-545,549,共4页
Journal of Huaihai Medicine
关键词
缺氧缺血
脑
神经生长因子
胞鳞胆碱
脑蛋白水解物
婴儿
新生
Hypoxic-ischemic
encephalopathy
Nerve growth factor
Citicoline
Cerebroprotein hydrolysate
Infant
newborn
