摘要
目的探讨3种不同内膜准备方案在玻璃化冻融囊胚移植周期中的应用。方法回顾性分析2012年1月至2015年12月间在我中心接受玻璃化冻融囊胚移植的1 264个周期的临床资料,根据内膜准备方案的不同分为3组:自然周期组(A组,467个周期,首次解冻周期移植);人工周期组(B组,725个周期,首次解冻周期移植);降调节+人工周期组(C组,72个周期,首次解冻周期移植未妊娠再次行解冻移植者),比较3组的一般资料及妊娠结局。结果A组的女方年龄显著高于B组,体重指数显著低于B组,基础FSH、移植日子宫内膜厚度显著高于B、C组(P均<0.05);A、B组的移植囊胚数显著低于C组(P<0.05)。A组优质囊胚率显著高于B、C组,B组显著高于C组(P<0.05)。3组间着床率、临床妊娠率、早期流产率、晚期流产率、早产率及活产率比较无显著性差异(P>0.05)。进行Logistic多因素回归分析提示,移植日内膜厚度、移植囊胚数及移植优质囊胚数是临床妊娠率的独立影响因素(P<0.05),内膜准备方案并不是临床妊娠率的影响因素(P>0.05)。结论对于<35岁月经周期规律的患者行首次或再次玻璃化冻融囊胚移植时,不同子宫内膜准备方案并不影响妊娠结局。
Objective：To explore the application of three different endometrial preparation protocols in the frozen-thawed blastocyst transfer cycles.Methods： A retrospective analysis was carried out on 1 264 cycles of vitrification thawed blastocyst transfer.According to different endometrial preparation protocols,the patients were divided into the natural cycle group（group A,the first thawed blastocyst transfer cycle,n=467）,the artificial cycle group（group B,the first thawed blastocyst transfer cycle,n=725）and the down-regulation artificial cycle group（group C,the down regulation artificial cycle after pregnancy failure of first thawed cycle,n=72）.The basic characteristics and pregnancy outcomes were compared among the three groups.Results：The female age was significantly older,but BMI was significantly lower in group A compared with group B（P〈0.05）.The basic FSH level and endometrial thickness in group A were significantly higher than those in group B and group C（P〈0.05）.The number of blastocyst transfer in group A and group B was significantly lower than that in group C（P〈0.05）.The quality blastocyst rate in group A was significantly higher than that in group B and group C（P〈0.05）,and the rate group B was significantly higher than group C（P〈0.05）.There were no significance differences in the implantation rate,clinical pregnancy rate,early abortion rate,later abortion rate,premature rate and live birth rate among the three groups（P〉0.05）.The logistic regression multivariate analysis showed that endometrium thickness,number of transplanted blastocysts and number of transplanted high quality blastocysts were independent factors（P〈0.05）,but endometrial preparation protocol was not the independent influence factor for clinical pregnancy rate（P〉0.05）.Conclusions：The endometrial preparation protocols do not affect pregnancy outcome for the patients less than 35 years old with a regular menstrual cycle,who underwent the first or second vitrification thawed blastocyst transfer cycle.
作者
张玉婷
苏迎春
ZHANG Yu-ting;SU Ying-chun(The Reproductive Medicine Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 45005)
出处
《生殖医学杂志》
CAS
2018年第9期892-897,共6页
Journal of Reproductive Medicine
关键词
内膜准备
玻璃化冷冻
囊胚移植
Endometrial preparation
Vitrification
Blastocyst transfer
