摘要
目的:了解日达仙的免疫调节作用。方法:选取18例重型肝炎病人用日达仙(Tα_1)治疗,并在治疗前后检测内毒素(LSP)、肿瘤坏死因子(TNF)、白细胞介素2受体(IL-2R)、白细胞介素4(IL-4)、白细胞介素6(IL-6),及T细胞亚群(CD_8^+、CD_4^+)。结果:治疗前LSP、TNF、IL-2R、IL-6、CD_8^+增高(P<0.01),而IL-4及CD_4^+降低。经Tα_1治疗后,LSP、TNF、IL-2R、IL-6、CD_8^+均降低(P<0.01),而IL-4和CD_4^+增高。结论:Tα_1是一种强有力的免疫调节剂,它能降低LSP、TNF、IL-2R、IL-6、CD_8^+,提升IL-4水平,从而减轻重型肝炎时免疫反应对肝细胞的损伤。
Aim: To study immune regulation of Tymosin a, (Tα1). Metheds: Eighteen patients with severe hepatitis were treated by Tα1. The levels of LSP. TNF, IL-2R, IL-4, IL-6, CD8+ , CD4+ in the sera were observed before and after Tα1 used. Results: Before treatment, the levels of LSP. TNF. IL-2R. IL-6. and CD8 were increased, and levels of IL-4 and CD4+ decreased. After treatment with Tα1, the levels of LSP. TNF IL-2R. IL-6 and CD8- were decreased, and levels of IL-4 and CD4+ increased. Conclusion: Tα1 is an effective immune regulatory factor. It can reduce immune damage of liver-cells in severe hepatitis.
出处
《中西医结合肝病杂志》
CAS
1999年第4期10-11,21,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
