摘要
Background： Base excision repair （BER） plays an important role in the maintenance of genome integrity and anticancer drug resistance. This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer （NSCLC） patients treated with platinum-based chemotherapy. Methods： During the period from November 2009 to January 2016, a total of 152 patients diagnosed with NSCLC Stage IIIB and IV in the First Hospital of Jilin University were admitted into this study. The XRCC1 G28152A, MUTYH G972C, HOGG1 C1245G. and PARPI T2444C polymorphisms of all the patients were detected by mass spectrometry. The logistic regression was used for statictical analysis. All tests were bilateral test, and a P 〈 0.05 was considered statistically significant. Results： The logistic regression model showed that the response rate of chemotherapy of the PARP1 T2444C polymorphisms, CC genotype （odds ratio [OR]： 5.216, 95% confidence interval [CI]： 1.568-17.352, P = 0.007）, TC genotype （OR： 2.692, 95% C1：1.007-7.198, P = 0.048）, as well as the genotype of TC together with CC （OR： 3.178, 95% CI： 1.229-8.219, P = 0.017） were significantly higher than those of TT wild type. There was no relationship between the MUTYH G972C, XRCC1 G28152A, and HOGGI C1245G gene polymorphisms and chemosensitivity. Conclusions： The PARPI 2444 mutation allele C might be associated with the decreased sensitivity to platinum-based chemotherapy in advanced NSCLC. These findings may be helpful in designing individualized cancer treatment.
Background： Base excision repair （BER） plays an important role in the maintenance of genome integrity and anticancer drug resistance. This study aimed to explore the role of BER gene polymorphisms in response to chemotherapy for advanced non-small cell lung cancer （NSCLC） patients treated with platinum-based chemotherapy. Methods： During the period from November 2009 to January 2016, a total of 152 patients diagnosed with NSCLC Stage IIIB and IV in the First Hospital of Jilin University were admitted into this study. The XRCC1 G28152A, MUTYH G972C, HOGG1 C1245G. and PARPI T2444C polymorphisms of all the patients were detected by mass spectrometry. The logistic regression was used for statictical analysis. All tests were bilateral test, and a P 〈 0.05 was considered statistically significant. Results： The logistic regression model showed that the response rate of chemotherapy of the PARP1 T2444C polymorphisms, CC genotype （odds ratio [OR]： 5.216, 95% confidence interval [CI]： 1.568-17.352, P = 0.007）, TC genotype （OR： 2.692, 95% C1：1.007-7.198, P = 0.048）, as well as the genotype of TC together with CC （OR： 3.178, 95% CI： 1.229-8.219, P = 0.017） were significantly higher than those of TT wild type. There was no relationship between the MUTYH G972C, XRCC1 G28152A, and HOGGI C1245G gene polymorphisms and chemosensitivity. Conclusions： The PARPI 2444 mutation allele C might be associated with the decreased sensitivity to platinum-based chemotherapy in advanced NSCLC. These findings may be helpful in designing individualized cancer treatment.
基金
This study was supported by grants from the National Key Research and Development Program of China （No. 2016YFC1303804）, the National Natural Science Foundation of China （No. 81672275 and No. 81501962）, the Key Laboratory Construction Project of Science and Technology Department （No. 20170622011JC）, the Industrial Research and Development Project of Development and Reform Commission of Jilin Province （No. 2017C022）, the State Key Program of National Natural Science of China （No. 31430021）, and the Youth Fund of the First Hospital of Jilin university （No. JDYY52015003）.
