摘要
Background： Estrogen is one of the most important reproductive steroidal hormones and plays a critical role in the maintenance of pregnancy, and its function is mediated by estrogen receptor 1 （ESR 1）. The polymorphisms ofESR 1 were involved in recurrent spontaneous abortion （RSA）; however, the association between ESRI polymorphisms and RSA remains controversial. The present meta-analysis was aimed to clarify the association between ESRI Pvull （-397C/T, rs2234693） and Xbal （-351 A/G, rs9340799） polymorphisms and the risk of RSA. Methods： All the included articles were retrieved from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Med Online Database up to January 3,2018. Data were processed in the Stata 12.0 software. The odds ratios （ORs） and 95% confidence intervals （95% Cls） were calculated using fixed-effects models （FEM）/random-effects models （REM）. Results： Seven case-control studies with 836 cases and 1164 controls were included in the study. Generally, the ESR 1 polymorphisms were not associated with RSA in any of the genetic analysis models. However, it was found that as rs9340799 polymorphism was related to increased risk of RSA in non-Asian group in the homozygous genetic model （OR = 2.40, 95% CI = 1.05-5.50, P = 0.039）. Moreover, in Asian group, rs9340799 polymorphism was found to be related to decreased RSA risk in both the heterozygous model （OR = 0.53, 95% CI = 0.33-0.85, P = 0.009） and the dominant genetic model （OR=0.55, 95% CI = 0.30 0.98, P = 0.042）. Conclusions： Generally. there was no significant association between the polymorphisms of ESRI and the risk of RSA. However, subgroup analysis indicated that ESR1 rs9340799 polymorphism was related to increased RSA risk in the non-Asian group while associated with decreased RSA risk in Asian group.
Background： Estrogen is one of the most important reproductive steroidal hormones and plays a critical role in the maintenance of pregnancy, and its function is mediated by estrogen receptor 1 （ESR 1）. The polymorphisms ofESR 1 were involved in recurrent spontaneous abortion （RSA）; however, the association between ESRI polymorphisms and RSA remains controversial. The present meta-analysis was aimed to clarify the association between ESRI Pvull （-397C/T, rs2234693） and Xbal （-351 A/G, rs9340799） polymorphisms and the risk of RSA. Methods： All the included articles were retrieved from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Med Online Database up to January 3,2018. Data were processed in the Stata 12.0 software. The odds ratios （ORs） and 95% confidence intervals （95% Cls） were calculated using fixed-effects models （FEM）/random-effects models （REM）. Results： Seven case-control studies with 836 cases and 1164 controls were included in the study. Generally, the ESR 1 polymorphisms were not associated with RSA in any of the genetic analysis models. However, it was found that as rs9340799 polymorphism was related to increased risk of RSA in non-Asian group in the homozygous genetic model （OR = 2.40, 95% CI = 1.05-5.50, P = 0.039）. Moreover, in Asian group, rs9340799 polymorphism was found to be related to decreased RSA risk in both the heterozygous model （OR = 0.53, 95% CI = 0.33-0.85, P = 0.009） and the dominant genetic model （OR=0.55, 95% CI = 0.30 0.98, P = 0.042）. Conclusions： Generally. there was no significant association between the polymorphisms of ESRI and the risk of RSA. However, subgroup analysis indicated that ESR1 rs9340799 polymorphism was related to increased RSA risk in the non-Asian group while associated with decreased RSA risk in Asian group.
作者
Xun-Qiang Yinl
Hong-Mei Ju
Qiang Guo
Lin Zhao
Xiao-Xiao Zhu
Ran Wei
Zhen Zhang
Yun-Hong Zhang
Bin Wang
Xia Li
Xun-Qiang Yin;Hong-Mei Ju;Qiang Guo;Lin Zhao;Xiao-Xiao Zhu;Ran Wei;Zhen Zhang;Yun-Hong Zhang;Bin Wang;Xia Li(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan,Shandong 250062,China;Laboratory for Molecular Immunology,Institute of Basic Medicine,Shandong Academy of Medical Sciences,Jinan,Shandong 250062,China;Department of Gynaecology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250011,China;Department of Peripheral Vascular Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250011,China)
基金
This work was supported by the Natural Science Foundation of China （No. 81373670, No. 81673981, and No. 81601442）, the Primary Research and Development Plan of Shandong Province （No. 2016GSF202016, No. 2017GSF19118, 2017G006018, and No. 2017GSF218013）, the Project of Transformation in High-tech Achievements （No. 2013ZHZX2A0405）, the Science and Technology Development Grant of the State Administration of traditional Chinese medicine of Shandong Province （No. 2013-2016 and No. 2017-174）, the Family Planning Committee of Shandong Province （No. [2014] 14）, the Project for Shandong Medical and Health Science and Technology Plan （No. 2015WS0191）, the Project of Science and Technology of Shandong Academy of Medical Sciences （No. 2016-34, No. 2016-35, and No. 2017-15）, and the Innovation Project of Shandong Academy of Medical Sciences.
