摘要
目的探讨国产血管内无载体含药物洗脱支架(Nano支架)治疗不稳定型心绞痛患者的安全性及有效性。方法选取在我院住院的不稳定型心绞痛患者,分为两组,比较术后12个月心血管事件、靶血管最小内膜腔面积、最小支架截面积及内膜增生面积。结果随访12个月,组1心血管事件7例,组2心血管事件6例,两组差异无统计学意义(P=0.727);术后12个月,组1共有4例患者因冠状动脉严重狭窄再次行支架植入术,组2共有3例再次行支架植入术,两组差异无统计学意义(P=0.672);术后12个月,两组靶血管内膜均有增生,差异无统计学意义(P=0.985);术后12个月两组患者靶血管最小内膜腔面积差异无统计学意义(P=0.921);两组患者最小支架截面积差异无统计学意义(P=0.934)。结论 Nano支架治疗不稳定型心绞痛患者临床疗和Endeavor Resolute支架相当,心血管事件较少、临床应用安全可靠。
Objective To study the safety and effectiveness of polymer-free sirolimus-eluting Nano stentin patients with unstable angina pectoris. Methods Three hundred and twenty-one patients with unstable anginapectoris were divided into Nano stent group（group A,n = 157）and Endeavor resolute stent group（group B,n =164）. The cardiovascular events were compared postoperative 12 months. The minimal intima cavity area and mini-mum bracket section area and neointimal area were compared postoperative 12 months by intravascular unltrasound（IVUS）. Results There were 7 cases of cardiovascular events in group A and 6 in group B postoperative 12 months（P = 0.727）and 2 patients in group A and 3 in group B were re-implanted stent because of restenosis post-operative 12 months（P = 0.672）. The neointimal area were（0.31 ± 0.11 mm2）in group A and（0.29 ± 0.12 mm2）in group B postoperative 12 months（P = 0.985）. The minimal intima cavity area（P = 0.921）and the minimumbracket section area（P = 0.934）were narrower postoperative 12 months than immediately after the operation in twogroups. Conclusion With less cardiovascular events and being safe and reliable,the clinical effect of polymer-free sirolimus-eluting Nano stent implantation is similar to that of Endeavor resolute stent implantation.
作者
陈新军
郑若龙
黄凤娇
杨增芯
徐卓文
李伟章
张华
CHEN Xinjun,ZHEN Ruolong,HUANG Fengjiao,YANG Zengxin,XU Zhuowen,LI Weizhang,ZHANG Hua(Department of Cardiology,Affiliated Jiangyin Hospital,College of Medicine,Southeast university, Jiangyin 214400, Chin)
出处
《实用医学杂志》
CAS
北大核心
2018年第12期2042-2045,共4页
The Journal of Practical Medicine
