摘要
建立了利用分析仪器确证头孢孟多酯钠化学结构的方法。通过元素分析仪分析头孢孟多酯钠的元素组成,并利用核磁共振(NMR)、质谱(MS)、红外光谱(IR)、紫外光谱(UV)对头孢孟多酯钠进行结构分析。通过解析确证,头孢孟多酯钠的结构为7-D-(2-甲酰氧苯乙酰胺)-3-[(1-甲基-1H-四唑-5-基)巯甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸盐。该方法准确可行,可为头孢孟多酯钠的结构鉴定提供依据。
A method was established for the chemical structure determination of cefamandole nafate by analytical instruments.The elemental analyzer was used to analyze the elemental composition of cefamandole nafate,and nuclear magnetic resonance,mass spectrometry,infrared spectrometry and ultraviolet spectrometry were adopted to analyze the chemical structure of cefamandole nafate.The chemical structure of cefamandole nafate was confirmed to be sodium 7-D-[(2-hydroxy-2 phenylacetyl)amino]3-{[(1-methyl-1 H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.This method is accurate and practical,which can provide a comprehensive reference for the structural identification of cefamandole nafate.
作者
林云良
高红梅
李锋
魏祥玉
王志伟
姜海龙
王岱杰
LIN Yun-liang;GAO Hong-mei;LI Feng;WEI Xiang-yu;WANG Zhi-wei;JIANG Hai-long;WANG Dai-jie(Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China)
出处
《山东科学》
CAS
2018年第3期113-118,共6页
Shandong Science
基金
国家自然科学基金青年基金(21506119)
关键词
头孢孟多酯钠
结构确证
波谱学
波谱特征
cefamandole nafate
structural identification
spectroscopy
spectroscopic characteristics
