摘要
目的探讨2型糖尿病(T2DM)周围神经病变(DPN)患者与外周血25-羟维生素D_3[25-(OH)D_3]和CD4^+调节性T细胞(Tregs)的关系。方法收集42例T2DM,根据临床症状、体征及电生理检查,将患者分为28例DPN组和14例非DPN组。采用电化学发光免疫法检测T2DM DPN组和非DPN组外周血25-(OH)D_3水平;用流式细胞仪检测所有患者CD4^+Tregs变化。结果(1)DPN组25-(OH)D_3水平比非DPN组低(P<0.05);(2)两组外周血CD4^+Tregs百分比比较,差异有统计学意义(P<0.05),神经病变组患者低;(3)T2DM DPN组外周血25-(OH)D_3与CD4^+Tregs百分比呈正相关(P<0.05)。结论25-(OH)D_3和CD4^+Tregs可能与T2DM患者DPN的发生有关。
Objective To investigate potential association between 25-hydroxyvitamin D3[25-（OH）D3],CD4＋regulatory T cells（Tregs）in peripheral blood and patients with type 2 diabetes peripheral neuropathy（DPN）.Methods A total of 42 cases with type 2 diabetes were enrolled into the study;28 patients were identified as DPN and14 cases as non-DPN according to clinical symptoms,signs and electrophysiological tests.Electrochemiluminescence immunoassay was performed to measure the peripheral blood 25-（OH）D3.CD4＋Tregs cells was measured by flow cytometry.Results Serum levels of 25-（OH）D3 decreased significantly in DPN group when compared with non-DPN（P〈0.05）.Percentage of CD4＋Tregs decreased significantly in DPN group when compared with nonDPN（P〈0.05）.Positive correlation between 25-（OH）D3 and percentage of CD4＋Tregswas identified（P〈0.05）.Conclusions Peripheral blood 25-（OH）D3 and the percentage of CD4＋Tregs may be related with the occurrence of DPN in patients with T2DM.
作者
秦宏超
张真稳
Hong-chao Qin;Zhen-wen Zhang(Department of Endocrinology,Clinical Medical School,Yangzhou University,Yangzhou,Jiangsu 225100,China)
出处
《中国现代医学杂志》
CAS
2018年第18期45-49,共5页
China Journal of Modern Medicine
基金
国家卫生和计划生育委员会课题(No:W201309)
