摘要
研究表明,疾病导致机体免疫功能的下降,围术期应激、手术创伤、炎症反应又进一步降低了机体免疫功能。近年来出现一系列右美托咪定(Dex)对各类手术患者免疫功能影响的研究,研究发现Dex能通过降低疼痛、降低应激作用和炎症反应以及减少围术期阿片类药物和吸入麻醉药物对机体免疫功能的抑制作用而改善手术患者的免疫抑制。目前Dex能在麻醉实施及术后管理中改善手术患者的免疫功能,为临床提供一些新的治疗依据,期望Dex能提高非手术患者的免疫功能。
Studies show that diseases will lead to the decrease of the immune function of the body,and the perioperative stress,surgical trauma,and inflammatory reaction further reduce the immune function of the body.In recent years,there are a series of studies on the effects of dexmedetomidine on immune function in patients with various types of surgery,and it＇s found that dexmedetomidine can reduce pain,reduce stress and inflammation and reduce perioperative opioid and inhalational anesthetics inhibition on immune function,thus to improve the immune suppression of surgical patients.At present,dexmedetomidine can improve the immune function of patients undergoing anesthesia and postoperative management,and provide some new evidence for clinical treatment,expecting that dexmedetomidine can improve the immune function of nonsurgical patients.
作者
杨惠茹
辛学东
解雅英
YANG Huiru;XIN Xuedong;XIE Yaying(Department of Anesthesiology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《医学综述》
2018年第11期2250-2254,共5页
Medical Recapitulate
关键词
右美托咪定
应激反应
炎症反应
疼痛
免疫抑制
Dexmedetomidine
Stress reaction
Imflanmatory reaction
Pain
hnnmne suppression
