摘要
目的采用Meta分析方法探讨中国人群强直性脊柱炎(AS)与内质网氨基肽酶1(ERAP-1)单核苷酸多态性(SNP)的相关性。方法检索2009—2016年发表的独立研究报道全文,ERAP-1 SNP等位基因频率和基因多态性依据原始数据计算获得。使用q检验分析文献异质性。计算合并效应量相对危险度(OR)和95%可信区间(CI)。结果共纳入9篇文献,分析中国AS患者(病例组)3 802例,对照组4 930名,共研究10个SNP位点,包括rs27980、rs27037、rs7711564、rs27434、rs27582、rs27044、rs30187、rs10050860、rs2287987和rs7711564。Meta分析显示,rs27037T是AS的危险位点[等位基因G相比于T,OR(95%CI)=1.22(1.12～1.33),P<0.000 01;基因型GG相比于TT+GT,OR(95%CI)=1.34(1.18～1.53),P<0.000 01]。rs30187C为AS的保护性位点[等位基因T相比于C,OR(95%CI)=0.83(0.68～1.00),P=0.05;基因型TT相比于CC+TC,OR(95%CI)=0.80(0.67～0.95),P=0.01]。其他9个SNP均与AS发病不相关(P>0.05)。结论中国人群AS发病与ERAP1基因多态性存在相关性。
Objective To investigate the correlation of endoplasmic reticulum aminopeptidase 1（ERAP-1）gene single nucleotide polymorphisms（SNP） with ankylosing spondylitis（AS） in Chinese by a Meta analysis. Methods Literatures published from 2009 and 2016 were searched. The frequencies of ERAP-1 gene SNP alleles and genotypes were obtained from original data. The heterogeneities were analyzed by q test. The pooled odds ratios（OR） and 95% confidence intervals（CI） were calculated. Results A total of 9 independent studies were included,and 3 802 Chinese AS cases and 4 930 control cases were enrolled. A total of 10 ERAP-1 gene SNP,including rs27980,rs27037,rs7711564,rs27434,rs27582,rs27044,rs30187,rs10050860,rs2287987 and rs7711564,were analyzed. The Meta analysis showed that rs27037T was a risk factor for AS in Chinese [OR（95%CI） of allele G to T was 1.22（1.12-1.33）,P〈0.000 01;OR（95%CI） of genotype GG to TT＋GT was 1.34（1.18-1.53）,P〈0.000 01],and rs30187C was a protective factor for AS in Chinese [OR（95%CI） of allele T to C was 0.83（0.68-1.00）,P=0.05;OR（95%CI）of genotype TT to CC＋TC was 0.80（0.67-0.95）,P=0.01]. Other 9 SNP had no correlation with AS in Chinese（P〉0.05）. Conclusions ERAP-1 gene polymorphisms are correlated with AS in Chinese.
作者
李琳芸
彭长华
梅冰
董莉
LI Linyun;PENG Changhua;MEI Bing;DONG Li(Department of Clinical Laboratory,Jingzhou Hospital,Tongji Medical College,Huazhong University of Science and Technology,Jingzhou 434020,Hubei,China;Department of Rheumatism and Immunity,Jingzhou Hospital,Tongji Medical College,Huazhong University of Science and Technology,Jingzhou 434020,Hubei,China)
出处
《检验医学》
CAS
2018年第6期481-485,共5页
Laboratory Medicine
