摘要
目的探讨朗格汉斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)临床病理特点、免疫表型、诊断、鉴别诊断及预后。方法分析15例儿童LCH临床资料及组织病理学特点,采用免疫组织化学法检测15例LCH和15例其他非LCH的组织细胞疾病(non-Langerhans cell histiocytic disorder,N-LCHD)Langerin、CD1a、S-100、CD68的表达情况,并分析其临床病理意义。结果 15例LCH的组织学特点:受累器官内朗格汉斯细胞弥漫增生,细胞圆形、卵圆形,核肾形、不规则形,见核沟及核皱褶。免疫组织化学特点:LCH和N-LCHD中Langerin表达率分别为100%和0%(P<0.05),CD1a表达率分别为93.3%和13.4%(P<0.05),S-100表达率分别为100%和86.7%(P>0.05),CD68表达率分别为26.7%和20.0%(P>0.05)。结论 LCH病理诊断中,Langerin和CD1a高度敏感且特异性强,可作为首选免疫组织化学指标。
Objective To investigate the clinicopathological features, immunophenotype, diagnosis, differential diagnosis and prognosis of Langerhans cell histiocytosis（LCH） in Langerhans.Methods Clinical data and histopathological features of 15 children with LCH were analyzed. The expression of Langerin, CD1a, S-100 and CD68 in 15 cases of LCH and 15 cases of non-Langerhans cell histiocytic disorder（N-LCHD） were detected by immunohistochemical method, and the clinical pathological significance was analyzed.Results Histological features of 15 cases of LCH： Langerhans cell of the affected organs proliferated and proliferated. The cells were round, oval, nuclear, and irregular. Immunohistochemical characteristics： the expression rates of Langerin in LCH and N-LCHD were 100% and 0% respectively（ P 〈 0.05）, and the CD1a expression rates were 93.3% and 13.4% respectively（ P 〈 0.05）. The expression rates of S-100 were 100% and 86.7% respectively（ P 〉 0.05）, and the CD68 expression rates were 26.7% and 20.0%, respectively（ P 〉 0.05）.Conclusion In the pathological diagnosis of LCH, Langerin and CD1a are highly sensitive and specific, and can be used as the first immunohistochemical index.
作者
张丽丽
刘玲
武强
安会波
李月红
ZHANG Li-li;LIU Ling;WU Qiang;AN Hui-bo;LI Yue-hong(Department of Pathology,Children′s Hospital of Hebei Province,Shijiazhuang 050031,China;Department of Neurosurgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Pathology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)
出处
《河北医科大学学报》
CAS
2018年第7期817-821,共5页
Journal of Hebei Medical University
