摘要
目的 :比较非风湿性房颤 (NRH AF)患者经胺碘酮和心律平复律后左房收缩功能的改变。方法 :利用多普勒超声观察了 2 5患者分别服用胺碘酮(简称胺碘酮组 ,n =13)和心律平 (心律平组 ,n =15 )复律后d 1、d 30时的房缩期二尖瓣血流 (MIF)和肺静脉血流 (PVF)变化 ,并与 15例正常人作对比。结果 :两组患者复律后d 1的房缩期二尖瓣血流峰速 (Ap) ,速度积分 (Ai)和房缩期肺静脉返转血流峰速 (Zp) ,速度积分 (Zi)均较正常显著减小 (P <0 .0 1) ,但两组之间无显著性差异。此后 4wk内两组患者的Ap、Ai、Zp和Zi均逐步增大 ,但复律后d30时两组患者的Ap、Ai、Zp和Zi都较正常组显著减小。与胺碘酮组患者相比 ,心律平组d 30时的Ap、Ai、Zp和Zi均显著减小 (P <0 .0 5 )。结论 :NRH AF患者经胺碘酮或心律平复律后一个月内左房收缩功能均不能完全恢复 ,且两组间改善程度不同 ,从复律后左房机械收缩功能的改善方面考虑 ,胺碘酮复律疗效优于心律平。
AIM: To compare left atrial systolic functions determined by echocardiography in cardioversion of nonrheumatic atrial fibrillation with amiodarone or propafenone. METHODS: 15 healthy volunteers and 25 patients with nonrheumatic atrial fibrillation were examined with the transmitral flow (TMF) doppler patterns at atrial constriction and the pulmonary venous flow (PVF) patterns during atrial systole on d 1 and d 30 after cardioversion with amiodarone (amiodarone group, n=13) or propafenone (propafenone group, n=15). RESULTS: Compared with the healthy volunteers, the flow both TMF and PVF lowered at atrial constriction in all patients on d 1 after cardioversion (P< 0.01 ), but there was not statistically significance between the amiodarone group and propafenone. There was a significant increase in the peak A wave velocity, velocity time integrals, the peak Z wave velocity and velocity time integrals during the four weeks in the all patients. Both TMF and PVF at atrial constriction also lowered in the two groups of patients respectively on d 30 in comparison with the volunteers. And the peak values of A wave velocity, velocity time integrals, the peak Z wave velocity and velocity time integrals decreased more obviously in propafenone group than in amiodarone group on d 30 (P< 0.05 ). CONCLUSION: Amiodarone is better than propafenone in cardioversion of nonrheumatic atrial fibrillation according to left atrial systolic functions determined by echocardiography.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2002年第5期421-423,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
安徽省教育厅自然科学基金课题 (№ 2 0 0 0jl2 42 )
