摘要
目的探讨益肾补骨汤联合椎体成形术对合并老年骨质疏松腰椎骨折患者的临床价值。方法选择2016年1月—2017年1月该院收治的合并骨质疏松的腰椎骨折患者80例,按照随机数字法分为两组,各40例。对照组均在局部麻醉下行开单门经皮椎体后凸成形术,观察组使用益肾补骨汤,比较治疗后1个月,相关部位骨密度测定结果,骨转化检测指标对比,并统计两组临床症状改善时间。结果治疗后1个月,观察组腰椎骨骨密度、全髋骨骨密度、股骨干骨密度水平分别为(1 192.1±35.6),(933.3±7.6)mg/cm^2和(903.4±11.9)mg/cm^2,明显大于对照组的(978.9±24.3)、(869.9±5.1)mg/cm^2和(876.5±7.8)mg/cm^2差异有统计学意义(t=31.283,43.810,11.957,P<0.05),观察组碱性磷酸酶水平为(95.3±4.1)U/L,大于对照组的(78.9±1.6)U/L,血清Ⅰ型胶原交联羧基末端肽水平为(0.17±0.01)μg/L低于对照组(0.28±0.02)μg/L差异有统计学意义(t=23.567,31.113,P<0.05),观察组下肢麻木缓解时间为(3.3±0.2)d,早于对照组的(5.6±0.4)d差异有统计学意义(t=32.527,P<0.05),腰腿部疼痛缓解时间(4.6±0.4)d,早于对照组的(7.7±0.6)d差异有统计学意义(t=27.189,P<0.05)。结论针对合并骨质疏松的腰椎骨折患者行经皮椎体成形术,联合应用益肾补骨汤,能显著改善骨密度,缓解患者临床症状,提高临床治疗效果。
Objective This paper tries to evaluate the clinical value of Yishen Buxu decoction combined with vertebroplasty in the treatment of senile osteoporosis lumbar fractures. Methods 80 cases with lumbar fracture complicated with osteoporosis admitted in this hospital from January 2016 to January 2017 were divided into two groups（n=40）. The control group underwent single-door percutaneous kyphoplasty under local anesthesia. The observation group was treated with Yishen Buxue Decoction. Compared with the bone mineral density measured at 1 month after treatment, the indexes of bone turnover were compared and statistically analyzed two groups of clinical symptoms. Results One month after treatment, the lumbar BMD, total hip BMD and femoral shaft BMD in the observation group were（1 192.1±35.6） mg/cm^2,（933.3±7.6）mg/cm^2 and（903.4±11.9）mg/cm^2, which were significantly higher than that of the control group（978.9 ±24.3） 、（869.9±5.1）mg/cm^2 and（876.5 ±7.8） mg/cm^2,the difference was statistically significan（t =31.283, 43.810 and 11.957, P〈0.05）, the alkaline phosphatase level was（95.3±4.1）U/L, which was significantly higher than that of the control group（78.9±1.6）U/L,Serum levels of Couagen type I crosslinking Carboxyl terminal peptide levels for（017±0.01）μg/L which was lower than that of the control group（0.28±0.02）μg/Lthe difference was statistically significan（t=23.567,31.113, P〈0.05）. The relief time of the lower extremities in the observation group was（3.3±0.2） d, shorter than the control group of（5.6±0.4） d,the difference was statistically significan（t=32.527, P〈0.05）. The relief time of lumbar and leg pain was（4.6±0.4） d, which was earlier than that of the control group（7.7±0.6） dthe difference was statistically significan（t=27.189, P〈0.05）. Conclusion Percutaneous vertebroplasty combined with Yishen Bugu Decoction can effectively improve the bone mineral density, relieve the clinical symptoms and improve the clinical effect in patients with lumbar fracture complicated with osteoporosis.
作者
杜成田
DU Cheng-tian(Department of Surgery,Zhanyuan Central Hospital of Lanshan District,Linyi,Shandong Province,276038 Chin)
出处
《系统医学》
2018年第3期24-26,共3页
Systems Medicine
