摘要
目的分析红细胞比容(HCT)、纤维蛋白原(Fg)及D-二聚体(D-D)与颈动脉斑块形成的相关性。方法回顾性分析2013年7月至2017年6月在我院心内科住院并行颈动脉彩超检查的283例病人的临床资料,分为斑块组(162例)和无斑块组(121例),检测并比较2组病人的HCT、Fg、D-D、平均红细胞体积(MCV)、纤维蛋白原降解产物(FDP)、血压及生化指标的差异。结果斑块组Fg、D-D、MCV、FDP、收缩压(SBP)、脉压(PP)、空腹血糖(FBG)、肌酐(CRE)、血尿酸(BUA)、血尿素氮(BUN)水平显著高于无斑块组,而HCT、舒张压(DBP)则显著低于无斑块组(P均<0.05)。Logistic多元回归分析显示,高龄、Fg升高、PP增大、FBG升高是颈动脉斑块形成的独立危险因素。结论 HCT、Fg、D-D等多种危险因素参与了颈动脉斑块的形成,其中Fg水平增高是颈动脉斑块形成的独立危险因素。
Objective To analyze the correlation of hematocrit（ HCT）,fibrinogen（ Fg）,D-dimer（ D-D） with carotid plaque. Methods The clinical data of 283 patients who underwent carotid ultrasonography in our hospital from January 2013 to June 2017 were analyzed retrospectively,the patients were divided into plaque group（ n = 162） and non-plaque group（ n = 121）. The levels of HCT,Fg,D-D,mean corpuscular volume（ MCV）,fibrinogen degradation products（ FDP）,blood pressure and biochemical indexes were detected and compared between the two groups. Results The levels of Fg,DD,MCV,FDP,systolic blood pressure（ SBP）,pulse pressure（ PP）,fasting blood glucose（ FBG）,creatinine（ CRE）,blood uric acid（ BUA） and blood urea nitrogen（ BUN） in plaque group were significantly higher than those in non-plaque group,while HCT and diastolic blood pressure（ DBP） were significantly lower than those in non-plaque group（ P〈0. 05）. Logistic multivariate regression analysis showed that age,increased PP,elevated FBG and elevated Fg were independent risk factors for carotid plaques formation. Conclusions Many risk factors,such as HCT,Fg and D-D might be related with the formation of carotid plaques,and the high level of Fg is an independent risk factor for the formation of carotid plaque.
作者
徐倩如
陈方圆
周碧蓉
XU Qian-ru;CHEN Fang-yuan;ZHOU Bi-rong.(Departerment of Cardiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Chin)
出处
《实用老年医学》
CAS
2018年第6期577-580,共4页
Practical Geriatrics
