摘要
目的探讨拉莫三嗪与丙戊酸钠联合治疗老年脑卒中后继发癫痫的临床价值。方法将86例老年脑卒中后继发癫痫患者按随机数表法分为观察组与对照组，每组43例。两组均给予常规脑卒中治疗，对照组给予丙戊酸钠治疗，观察组在对照组基础上给予拉莫三嗪治疗，对比两组临床疗效、癫痫发作频率、癫痫发作持续时间、神经功能缺损程度及不良反应发生率。结果观察组总有效率高于对照组，差异有统计学意义（P〈0．05）。观察组治疗后6个月、1年癫痫发作频率、癫痫发作持续时间均低于对照组，差异有统计学意义（P〈0．05）。观察组治疗后6个月、1年NIHSS评分低于对照组，差异有统计学意义（P〈0．05）。两组不良反应发生率比较差异未见统计学意义（P〉0．05）。结论与单纯丙戊酸钠治疗相比，拉莫三嗪与丙戊酸钠联合治疗老年脑卒中后继发癫痫临床疗效更好，可降低癫痫发作频率、癫痫发作持续时间，而且有利于神经功能恢复，用药也较安全。
Objective To investigate the clinical value of lamotrigine combined with sodium valproate on epilepsy in elderly patients after stroke. Methods Eighty-six elderly patients with secondary epilepsy after stroke were randomly divided into observation group and control group, with 43 cases in each group. The two groups were given routine treatment of stroke, and the control group was given sodium valproate treatment. On the basis of the treatment in the control group, the observation group was treated with lamotrigine treatment. The clinical efficacy, the frequency of epileptic seizures, the duration of epileptic seizures, the degree of neural function defect and the incidence of adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group （P 〈 0. 05 ）. After 6 months of treatment and 1 year after treatment in the observation group, the seizure frequency and duration of epileptic seizures were lower than those in the control group （ P 〈 0. 05 ）. After 6 months of treatment and 1 year after treatment in the observation group, the score of NIHSS was lower than that of the control group （ P 〈 0. 05 ）. There was no significant difference in the incidence of adverse reactions between the two groups （ P 〉 0.05 ）. Conclusions Compared with sodium valproate, lamotrigine and sodium valproate has better effect on elderly patients after stroke secondary epilepsy, which can reduce the frequency of seizures, seizure duration, but also is conducive to the recovery of neurological function, and the medication is safe.
作者
陈丽
耿飞
Chen Li;Geng Fei(Department of Neurology, the 154th Hospital of PLA, Xinyang 464000, China;Department of Neurosurgery, the 154th Hospital of PLA, Xinyang 464000, Chin)
出处
《中国实用医刊》
2018年第12期103-105,109,共4页
Chinese Journal of Practical Medicine
关键词
拉莫三嗪
丙戊酸钠
老年
脑卒中
癫痫
Lamotrigine
Sodium valproate
Eblerly
Stroke
Epilepsy
