摘要
杂环烯酮缩胺(HKAs)是一类构建分子多样性稠杂环化合物的多功能合成砌块,已被广泛应用于构筑多种多样的类天然杂环化合物和合成药物中。随着杂环烯酮缩胺研究的深入开展,其作为双亲核试剂与多种亲电底物反应取得了较大的进展。本文将基于HKAs的结构特征、反应性能,对以HKAs及1,1-烯二胺为合成子构建各种类型具有潜在生物活性的类天然多环稠杂环化合物进行综述。
Heterocyclic ketene aminals （HKAs） are a class of fascinating and versatile synthetic building blocks for use in the construction of a wide range of molecular diversity fused heterocyclic compounds and synthetic drugs. With the further development of HKAs, great progress has been made in reactions of HKAs as a binucleophilic reagents with a variety of electrophilic substrates. Based on the structural characteristics and reaction performances of HKAs, construction of a variety of potentially bioactive natural-like polycyclic heterocyclic compounds with HKAs and 1,1-enediamine as synthons is reviewed herein.
作者
孔令斌
严胜骄
林军
Lingbin Kong;Shengjiao Yan;Jun Lin(Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2018年第5期639-657,共19页
Progress in Chemistry
基金
国家自然科学基金项目(No.U1202221
21662042
21362042
21262042
81160384)资助~~
