摘要
目的探讨静脉注射丙种球蛋白在预防早产儿深静脉置管时真菌感染中的价值。方法选取2015年8月-2017年4月医院监护的早产儿126例,按照随机数字表法将其分为试验组与对照组,每组各63例;两组均采取基础措施预防感染,试验组在此基础上实施静脉注射丙种球蛋白预防感染;比较两组早产儿感染发生情况、治疗相关指标及免疫球蛋白(IgG、IgA、IgM)、超敏C-反应蛋白(hs-CRP)和外周血白细胞(WBC)水平。结果试验组真菌感染例数少于对照组(χ~2=4.881,P=0.027);试验组抗菌药物使用时间、体温稳定时间、停氧时间、摄奶达正常半量时间及住院时间均短于对照组(P<0.05);两组早产儿治疗前后IgA、IgM水平比较差异无统计学意义,治疗后试验组IgG水平优于对照组(χ~2=0.838,P<0.001);治疗后两组早产儿hs-CRP、WBC水平均低于治疗前(P<0.05),试验组WBC水平优于对照组(χ~2=0.622,P<0.001)。结论早产儿临床应用静脉注射丙种球蛋白,可增强早产儿免疫功能,有效降低真菌感染率,并减少抗菌药物使用天数,缩短住院时间。
OBJECTIVE To explore the value of intravenous injection of gamma globulin in prevention of fungal infections in preterm infants during deep venous catheterization.METHODS A total of 126 preterm infants who were under the care of the hospital from Aug 2015 to Apr 2017 were enrolled in the study and randomly divided into the experimental group and the control group,with 63 cases in each group.The basic prevention measures were taken by both groups,and the experimental group was treated with intravenous injection of gamma globulin for prevention of infections on basis of the treatment.The incidence of infections,treatment-related indexes and levels of immunoglobulins（IgG,IgA,IgM）,high-sensitivity C-reactive protein（hs-CRP）and peripheral blood white blood cell（WBC）were observed and compared between the two groups of preterm infants.RESULTS The number of cases of fungal infections was significantly less in the experimental group than in the control group（χ~2=4.881,P=0.027）.The time of use of antibiotics,time of stabilization of body temperature,oxygen stopping time,time of milk intake′reaching to half of normal dose and length of hospital stay were significantly shorter in the experimental group than in the control group（P〈0.05）.There were no significant differences in the levels of IgA and IgM between the two groups of preterm infants before the treatment,the IgG level of the experimental group was significantly higher than that of the control group after the treatment（χ2=0.838,P〈0.001）.The levels of hs-CRP and WBC of the two groups of preterm infants were lower after the treatment than before the treatment（P〈0.05）,and the WBC level of the experimental group was significantly higher than that of the control group（χ2=0.622,P〈0.001）.CONCLUSION The intravenous injection of gamma globulin may intensify the immune function of the preterm infants,effectively reduce the incidence of fungal infections,reduce the days of use of antibiotics and shorten the length of hospital stay.
作者
闫萍
徐文
付红萍
夏凡
田苗
YAN Ping;XU Wen;FU Hong-：ping;XIA Fan;TIAN Miao(Zhongnan Hospital of Wuhan University, Wuhan , Hubei 430071, China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第10期1559-1562,共4页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(81300555)
关键词
丙种球蛋白
深静脉置管
真菌感染
Gamma globulin
Deep venous catheterization
Fungal infection
