摘要
肝脏是人体最大的代谢器官,肝脏任何损伤都可能导致全身稳定状态的改变。肝脏缺血再灌注损伤(hepatic ischemia reperfusion injury,HIRI)是临床常见的导致脂肪肝、非酒精性肝硬化和肝癌等疾病患者进行肝移植后肝功能受损的重要原因。细胞凋亡(apoptosis)是细胞自主、有序的死亡,过程复杂,参与因素多。凋亡可以清除肝内受损的细胞,维持肝功能。故在HIRI中如何维持细胞凋亡的稳定状态成为保肝的关键。研究显示,多种非药物性处理可平衡HIRI中细胞凋亡,减少肝损伤。该文就近几年非药物性处理抑制缺血再灌注(ischemia reperfusion,IR)肝脏细胞凋亡作用的研究进展(如对凋亡诱导因素、凋亡信号转导通路、凋亡通路下游分子等)作一综述。
Liver is the largest metabolic organ of human body, and its damage may lead to dyshomeostasis. Hepatic ischemia reperfusion injury（HIRI） is a crucial factors of liver dysfunction after liver transplantation for the patients suffered from fatty liver, non-alcoholic cirrhosis and liver cancer. As an autonomous and orderly death model, apoptosis can eliminate the damaged cells from the liver and improve its function. Hence, it is important to maintain the stable state of apoptosis in order to protect the liver from HIRI. Numerous studies have shown that non-drug treatments were helpful to promote apoptosis balance and reduce liver damage during HIRI. Here, this review summarized the progresses in the inhibitory effects of non-drug treatments on liver cells apoptosis during hepatic ischemia reperfusion injury, which involved the apoptosis inducing factors, its signal transduction pathway and its downstream molecules in recent years.
作者
王佩佩
黄霞
黄力欢
洪芬芳
杨树龙
Wang Peipei;Huang Xia;Huang Lihuan;Hong Fenfang;Yang Shulong(Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China;Department of Experimental Teaching Center, Nanchang University, Nanchang 330006, China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第4期608-616,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81660151
81260504
81660751)
江西省重点研发计划(批准号:20161BBG70067)
江西省自然科学基金(批准号:20171BAB205085)资助的课题~~
