摘要
目的研究匹多莫德对抗生素相关性腹泻(ADD)患儿的免疫球蛋白、T细胞亚群及炎症因子的影响。方法研究对象选取我院2015年12月至2017年2月收治的ADD患儿112例,采用随机数字法将其分为对照组和观察组,每组56例。对照组患儿接受常规对症治疗,观察组患儿在此基础上,口服匹多莫德治疗。比较两组患儿的疗效、复发率,以及治疗前后的血清免疫球蛋白、T细胞亚群及炎症因子水平。结果观察组的治疗总有效率(92.86%)明显高于对照组(73.21%)(χ~2=7.67,P<0.01);观察组的复发率明显低于对照组(χ~2=6.24,P=0.01);治疗后,观察组的血清IgA、IgG、IgM水平均明显高于对照组(P<0.01),CD3^+、CD4^+及CD4^+/CD8^+比值均明显高于对照组(P<0.01),CD8+明显低于对照组(P<0.01),血清TNF-α和IL-6水平均明显低于对照组(P<0.01)。结论匹多莫德辅助治疗小儿ADD的临床疗效显著,能有效改善患儿病情,抑制炎症反应,促进机体免疫功能恢复,值得在临床推广。
Objective To study the effects of pidotimod on immunoglobulin,T cell subsets and inflammatory cytokines in children with antibiotic-associated diarrhea（ ADD）. Methods Totally 112 children with ADD in our hospital from December 2015 to February 2017 were randomly divided into control group and observation group,56 cases in each group. Control group was treated with conventional symptomatic treatment,while observation group received pidotimod besids conventional symptomatic treatment. The curative effect,recurrence rate and the levels of serum immunoglobulin,T lymphocyte subsets,inflammatory cytokines before and after treatment were recorded and compared between the two groups. Results The total efficiency of observation group（ 92. 86%） was significantly higher than that of control group（ 73. 21%）（ χ^2= 7. 67,P〈0. 01）; the recurrence rate of the observation group was significantly lower than that of control group（ χ^2= 6. 24,P = 0. 01）. After treatment,the serum levels of Ig A,Ig G and Ig M and CD3^＋,CD4^＋and CD4^＋/CD8^＋ratio of observation group were higher than those of control group（ P〈0. 01）,while CD8^＋and serum levels of TNF-αand IL-6 were significantly lower than those of control group（ P〈0. 01）. Conclusion In children with ADD,conventional symptomatic treatment combined with pidotimod has significant clinical effect. It can effectively improve the condition,inhibit the inflammatory response,and promote the recovery of immune function. It is worthy of clinical promotion.
作者
蒋国丞
蒋瑾
杨拾梅
JIANG Guo-cheng;JIANG Jin;YANG Shi-mei(Yiwu Maternity and Child Care Family Planning Service Center, Yiwu 322000, Chin)
出处
《实用药物与临床》
CAS
2018年第5期557-560,共4页
Practical Pharmacy and Clinical Remedies
