摘要
G protein coupled receptors(GPCRs)are transmembrane receptor proteins,which allow signals to transfer across membrane.GPCRs include a large number of receptors,different receptors mediated different signaling pathways of GPCRs-adenylyl cyclase(AC)-cyclic adenosine 3',5'-monophosphate(c AMP),including β2 adrenergic receptors(β2-ARs)-AC-c AMP signaling pathways,E-prostanoid2/4(EP2/4)-AC-cA MP signaling pathways.Regulatory proteins,such as G protein coupled receptor kinases(GRKs)andβ-arrestins,play important modulatory roles in GPCRs signaling pathway.GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response.Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response.This article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.
G protein coupled receptors （GPCRs） are transmembrane receptor proteins, which allow signals to transfer across membrane. GPCRs include a large number of receptors, different receptors mediated different signaling pathways of GPCRs-adenylyl cyclase （AC）-cyclic adenosine 3＇ ,5＇- monophosphate （cAMP）, including 132 adrenergic receptors （132-ARs）-AC-cAMP signaling pathways, E-prostanoid2/4 （EP2/4）-AC-cAMP signaling pathways. Regulatory proteins, such as G protein coupled receptor kinases （GRKs） and IB-arrestins, play important modulatory roles in GPCRs signaling pathway. GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response. Rheumatoid arthritis （RA） is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response. This article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第10期970-970,共1页
Chinese Journal of Pharmacology and Toxicology
基金
supported by National Natural Science Foundation of China(81330081,81473223and 81673444)
Anhui Province Postdoctoral Science Foundation(2016B134)
