摘要
目的调查分析2011年1月至2016年12月重庆市渝西片区手足口病(HFMD)流行情况及变化趋势,科学制定防控策略,为该病的防控提供参考。方法采用实时荧光定量聚合酶链反应对2011年1月至2016年12月重庆市渝西片区7个区县和1个地市级医院收治的HFMD患儿标本进行核酸检测,并对病原学监测结果进行统计分析。结果 2011年1月至2016年12月年重庆市渝西片区累计报告HFMD临床病例2 655例,核酸检测阳性1 503例(56.61%)。不同性别患儿核酸检测阳性率、柯萨奇病毒A组16型(Cox A16)阳性率比较,差异均有统计学意义(P<0.05);不同性别患儿肠道病毒71型(EV71)、其他肠道病毒阳性率比较,差异均无统计学意义(P>0.05);2011年1月至2013年12月HFMD患儿标本核酸检测阳性率呈上升趋势,2013年最高,2014年1月至2016年12月有所下降;2011年1月至2014年12月HFMD主要以EV71、Cox A16流行为主,2015、2016年其他肠道病毒为优势病原;各年度核酸检测阳性率比较,差异有统计学意义(χ2=169.192,P=0.000);年龄分布以4岁以下儿童为主[52.43%(1 392/2 655)];铜梁县核酸检测阳性率最高[11.22%(298/2 655)],检测阳性病例中铜梁县比例最高[21.29%(320/1 503)]。结论重庆市渝西片区HFMD监测结果表明,HFMD常年均有发生,2011年以Cox A16、EV71为主,逐渐转变为其他肠道病毒。每年阳性构成比有差异,不同年龄、性别、地区HFMD患儿核酸检测阳性率有差异。
Objective To analyze the epidemiological status and the epidemiological tendency of hand,foot mouth dis-ease from January 2011 to December 2016 in the western chongqing area,to formulate the scientific prevention and controlstrategy and provide potential methods for the control of the disease.Methods The real-time fluorescence quantitative poly-merase chain reaction（RT-PCR）was used to detect the specific nucleic acid of hand,foot mouth disease children in seven dis-tricts and one prefectural and municipal hospitals in the western Chongqing area from January 2011 to December 2016,and theetiology monitoring results were analyzed.Results A total of 2 655 cases of clinical history with hand,foot mouth disease werereported,and 1 503（56.61%）specimens were positive detection of nucleic acid. The positive rate of nucleic acid detectionand the positive rate of coxsackievirus A group 16（Cox A16）were statistically significant（P〈0.05）.There was no significantdifference in the positive rate of enterovirus 71（EV71）and other enterovirus among different sex children（P〈0.05）.The posi-tive rate of nucleic acid detection in hand,foot mouth disease children from January 2011 to December 2013 showed an upwardtrend,the highest in 2013,The descended from 2014 to 2016,and mainly in EV71 and Cox A16 from January 2011 to 2014,and other enterovirus in 2015—2016 as the dominant pathogen,and the positive rate of nucleic acid detection in each year wasstatistically significant（χ2=169.192,P=0.000）;the age distribution was mainlyfor children under 4 years of age [52.43%（1392/2 655）;the positive rate of nucleic acid detection in Tongliang county was the highest（298/2 655））,and the highest pro-portion of Tongliang county was [21.29%（320/1 503）in the positive cases.Conclusion The results of hand,foot mouth dis-ease monitoring in the western Chongqing section of Chongqing showed that hand,foot mouth disease had occurred all the yearround from January 2011 to Deceber 2016.In 2011,Cox A16 and EV71 are the main ones,and they are gradually changed intoother enterovirus.The positive constituent ratio is different each year,and the positive rate of nucleic acid detection in childrenwith HFMD is different in different age,sex and area.
作者
周宗俞
周宗良
周杨
ZHOU Zongyu;ZHOU Zongliang;ZHOU Yang(Chongqing Yongchuan District Center for disease prevention and control, Chongqing 402160, China)
出处
《现代医药卫生》
2018年第9期1338-1341,共4页
Journal of Modern Medicine & Health
关键词
手足口病
病原
逆转录聚合酶链反应
肠道病毒A型
人
柯萨奇病毒感染
Hand,foot and mouth disease
Noxae
Reverse transcriptase polymerase chain reaction
Enterovirus A,human
Coxsackievirus infections
