摘要
目的提供老年非霍奇金淋巴瘤（NHL）患者老年综合评估（CGA）评分的分布数据；对比美国东部肿瘤协作组（ECOG）体力状况评分与CGA评分的差异。方法将北京医院血液科2014年2月至2017年2月收治的≥60岁NHL患者进行CGA评分，包括日常生活活动功能评定量表（ADL）、工具性日常生活活动功能评估量表（IADL）和改良老年疾病累计评分表（MCIRS-G），依据量表得分及年龄将患者分为适合组、不适合组和脆弱组。采用横断面研究，了解其临床特征，分析CGA评分分布，并对比ECOG体力状况评分与CGA评分的差异。结果64例老年NHL患者纳入研究。根据CGA评估，适合组占51.6%（33例），不适合组占12.5%（8例），脆弱组占35.9%（23例）；大多数患者有合并症，其中心血管疾病、糖尿病、高血压病较为常见；在60~64岁较年轻的患者中仍有25%（3/12）的患者CGA评估为＂脆弱＂，在≥80岁的高龄患者中＂脆弱＂比例达42.9%（6/14）；ECOG体力状况评分≤1分的患者中仍有38.9%（21/54）存在CGA受损。结论依据CGA评估，60岁及以上NHL患者中近一半存在CGA受损；在ECOG体力状况评分≤1分的患者中仍有部分患者存在CGA受损，提示ECOG评分会低估老年NHL患者功能受损程度。
ObjectiveTo measure the comprehensive geriatric assessment （CGA） in elder non-Hodgkin＇s Lymphoma （NHL） patients in a cross-sectional study; to compare the differences between Eastern Cooperative Oncology Group （ECOG）-performance status （PS） and CGA.MethodsCGA stratification included the following 3 instrument assessments： activity of daily living （ADL）;instrumental activity of daily living （IADL）;comorbidity score according to the modified cumulative illness rating score for geriatrics （MCIRS-G）. According to CGA and age, NHL patients, aged ≥60 years, were classified as＂fit＂,＂unfit＂and＂frail＂groups. ECOG-PS was evaluated and compared with CGA.ResultsAccording to CGA, 51.6% senior NHL patients （33 cases） were classified as＂fit＂, 12.5%（8 cases） as＂unfit＂and 35.9%（23 cases） as＂frail＂. Several comorbidities were observed in majority patients, such as cardiovascular disease, diabetes mellitus and hypertension. In the＂younger aged＂patients between 60 to 64ys, 25%（3/12） was considered as＂frail＂. However, this proportion increased to 42.9%（6/14） in patients older than 80ys. Moreover, impaired CGA was observed in 38.9%（21/54） of ECOG-PS ≤1 patient.ConclusionsImpaired CGA is as common as approximately half in elderly NHL patients and more than one third even in ECOG-PS ≤1 patients. ECOG-PS may underestimate the impaired fitness function in elder NHL patients.
作者
刘辉
高铭
梅迪
韩惠秀
李江涛
白洁菲
张春丽
冯茹
魏建平
田园
王婷
Liu Hui;Gao Ming;Mei Di;Han Huixiu;Li Jiangtao;Bai jiefei;Zhang Chunli;Feng Ru;Wei Jianping;Tian Yuan;Wang Ting.(Department of Hematology, Beijing Hospital, Beijing 100730, China)
出处
《中华内科杂志》
CAS
CSCD
北大核心
2018年第5期330-334,共5页
Chinese Journal of Internal Medicine
