摘要
目的探讨男性新诊断2型糖尿病(T2DM)患者中心性肥胖与高尿酸血症(HUA)的相关性。方法回顾性收集2015年7月至2017年7月我科男性新诊断T2DM患者170例,依据腰围(WC)将研究对象分为对照组及中心性肥胖组(男性WC≥90 cm)。比较两组的一般临床资料及生化指标。采用Logistic回归方法分析HUA发生的影响因素,使用工作曲线(ROC)及约登指数最大值作为分析新诊断T2DM患者WC判断HUA的界值及评价。结果 (1)中心性肥胖组的吸烟率低于对照组,BMI≥24 kg/m2比例、HUA发生率、收缩压(SBP)、三酰甘油(TG)、空腹血糖(FPG)、尿微量蛋白/肌酐比值(UACR)及血尿酸(SUA)均高于对照组。(2)Pearson相关分析结果显示,男性新诊断T2DM患者WC与SUA呈正相关关系,相关系数r为0.422,P<0.05。(3)Logistic回归分析显示,中心性肥胖及低高密度脂蛋白胆固醇(HDL-C)是HUA发生的危险因素。(4)ROC曲线分析显示,男性WC为88.5 cm时曲线下面积最大0.706(95%CI=0.628~0.785,P=0.000),敏感度79.4%,特异度57.0%。结论中心性肥胖及低HDL-C是男性新诊断T2DM患者HUA发生的危险因素,男性WC为88.5 cm是筛检HUA的最佳界值。
Objective To investigate the relationship between central obesity and hyperuricemia in male patients with newly- diagnosed type 2 diabetes mellitus （T2DM）. Methods A total of 170 male patients with newly-diagnosed T2DM in our department from July 2015 to July 2017 were selected and divided into two groups according to waist circumference （WC）： control group and central obesity group （WC≥ 90 cm）. The clinical data and biochemical characteristics were compared between the two groups. The factors influencing the incidence of HUA were analyzed by Logistic regression method. ROC curve and the maximum number of Jorden indices were used to analyze the boundary value and evaluation of WC in predicting HUA in newly-diagnosed T2DM patients. Results Newly-diagnosed T2DM patients with central obesity had lower smoking rate, higher proportion of BMI ≥ 24 kg/m2, higher incidence of HUA, and higher levels of SBP, TG, FPG, UACR and SUA than the control group. Pearson correlation analysis showed that WC and SUA were positively related in the male patients with newly diagnosed T2DM, and the correlation coefficient （r） was 0.422, P 〈0.05. Logistic regression analysis showed that central obesity and low HDL-C were the independent risk factors of HUA. The ROC curve of WC in predicting the risk of HUA showed that when WC was 88.5 cm, the area under the curve was the largest 0.706 （95%CI = 0.628 - 0.785, P= 0.000）. The sensitivity was 79.4% and the specificity was 57.0%. Conclusions Central obesity and low HDL-C are the risk factors for HUA in male patients with newly-diagnosed T2DM. The optimal cut-off point of WC for the diagnosis of HUA is 88.5 cm in male patients.
作者
桑丹
陆泽元
柳岚
曾玲
蒋凤秀
庄雄杰
SANG Dan;LU Zeyuan;LIU Lan;ZENG Ling;JIANG Fengxiu;ZHUANG Xiongjie(Department of Endocrinology, the Eighth Affiliated Hospital of Sun Y at-sen University （Futian Shenzhen） , Shenzhen 518033, China)
出处
《临床医学工程》
2018年第4期444-446,共3页
Clinical Medicine & Engineering
基金
深圳市卫生计生系统社区适宜技术研究及推广项目(项目编号:SZSJ2017003)
关键词
新诊断
2型糖尿病
中心性肥胖
高尿酸血症
Newly-diagnosed
Type 2 diabetes mellitus （T2DM）
Central obesity
Hyperttricemia （HUA）
