摘要
目的探讨IL-1受体拮抗剂(IL-1Ra)在炎症性肠病(IBD)患者血清中的表达及临床意义。方法选取71例活动期IBD患者为观察组,其中克罗恩病(CD)34例、溃疡性结肠炎(UC)37例;选取同期健康体检的49例体检者为对照组。采用ELISA法检测受检者血清IL-1Ra水平,分析血清IL-1Ra水平与疾病活动度的关系。结果 UC组、CD组、对照组血清IL-1Ra水平分别为(5.16±0.83)、(4.13±0.64)、(1.86±0.17)pg/ml,差异有统计学意义(P<0.01);进一步两两比较,UC组、CD组血清IL-1Ra水平均高于对照组(均P<0.01)。UC组、CD组不同疾病活动度患者的血清IL-1Ra水平比较,差异均有统计学意义(均P<0.01)。结论IBD患者血清IL-1Ra水平明显升高,且与UC、CD活动性有关。
Objective To investigate serum levels of IL-1 receptor antagonist（IL-Ra） in patients with inflammatory bowel disease（IBD） and its clinical significance. Methods Seventy one IBD patients, including 34 cases of crohn disease（CD） and 37 cases of ulcerative colitis（UC）, were recruited in Zhejiang Hospital from January 2016 to December 2016, and 49 healthy subjects（control group） were also included in the study. ELISA was applied to detect the serum IL-Ra levels in patients and healthy individuals. Results The serum levels of IL-Ra in UC, CD and control groups were（5.16±0.83） pg/ml,（4.13±0.64）pg/ml and（1.86±0.17） pg/ml, respectively（P〈0.01）. Serum IL-Ra levels in UC and CD patients were increased with disease activity increasing,（P〈0.01）. Conclusion Serum IL-Ra levels are significantly increased in IBD patients as compared to healthy individuals, and it may be a promising indicator for assessing IBD disease activity.
作者
冯玉良
何巧娜
周锋
朱琴
王卫峰
郑培奋
FENG Yuliang;HE Qiaona;ZHOU Feng;et al(Department of Gastroenterology, Zhejiang Hospital, Hangzhou 310013, China)
出处
《浙江医学》
CAS
2018年第8期833-835,共3页
Zhejiang Medical Journal
基金
浙江省自然科学基金项目(Y17H030031)
关键词
炎症性肠病
溃疡性结肠炎
克罗恩病
IL-Ra
Inflammatory
Ulcerative colitis
Crohn disease
Interleukin-1 receptor antagonist
