摘要
目的探讨糖皮质激素联合丙种球蛋白对小儿肺炎临床症状和炎症指标的影响。方法选取2015年4月至2017年4月烟台市中医医院儿科收治住院的肺炎患儿80例,随机分为联合治疗组和单独治疗组各40例。两组患儿均给予常规支持治疗。单独治疗组静脉注射丙种球蛋白;联合治疗组静脉滴注甲泼尼龙注射液和强的松注射液,同时给予患儿静脉滴注丙种球蛋白。3~5d为1个疗程。观察两组临床疗效、患儿症状体征消失时间及住院时间、患儿血清炎症指标水平。结果联合治疗组患儿治疗总有效率为92.5%(37/40),显著高于单独治疗组70.0%(28/40),差异有统计学意义(P<0.05)。联合治疗组退热时间、止咳时间、啰音消失时间、阴影吸收时间、住院时间均显著短于单独治疗组,差异有统计学意义(P<0.05)。联合治疗组血清白细胞计数、C反应蛋白、降钙素原水平均显著低于单独治疗组,差异有统计学意义(P<0.05)。结论糖皮质激素联合丙种球蛋白较单独丙种球蛋白治疗小儿肺炎更能有效改善患儿的临床症状降低患儿的血清炎症指标水平。
Objective To investigate the effect of glucocorticoid combined with gamma globulin on clinical symptoms and inflammatory markers in children with pneumonia.Methods A total of 80 cases of pediatric pneumonia in our hospital from April 2015 to April 2017 were selected,and according to the treatment methods,these patients were divided into glucocorticoid plus gamma globulin treatment group（combined treatment group,n=40）and single gamma globulin treatment group（single treatment group,n=40）.Both groups were given conventional supporting treatment.The single treatment group received intravenous injection of gamma globulin.The combined treatment group received intravenous dripping of methylprednisolone injection and prednisone injection in addition to gamma globulin.The treatment lasted for 3 to 5 day as a course.Observe the clinical effect,the time for symptoms and signs to disappear,length of hospital stay and the serum level of inflammatory markers in the two groups.Results The total effective rate of combined treatment group was 92.5%（37/40）,significantly higher than that of the single treatment group（70.0%,28/40）（P〈0.05）.The time for fever,cough and rales to disappear and the time of shadow absorption as well as the length of hospital stay in the combined treatment group were significantly shorter than the single treatment group（P〈0.05）.The level of WBC count,CRP and PCT was significantly lower in the combined treatment group than in the single treatment group（P〈0.05）.Conclusion Compared with gamma globulin alone,glucocorticoid combined with gamma globulin can effectively improve the clinical symptoms of children with pneumonia,and reduce the level of serum inflammatory markers in children.
作者
薛飞
汪受传
XUE Fei;WANG Shouchuan(Yantai Traditional Chinese Medicine Hospital ,Yantai 264000 ,Chin)
出处
《中国中西医结合儿科学》
2018年第2期93-95,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
国家自然科学基金项目(81373688)
关键词
肺炎
糖皮质激素
丙种球蛋白
临床症状
炎症指标
儿童
Pneumonia
Glucocorticoid
Gamma globulin
Clinical symptoms
Inflammatory markers
Child
